ArticleBMC evolutionary biology2008
Duplications and functional divergence of ADP-glucose pyrophosphorylase genes in plants.
Article in BMC evolutionary biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Phosphorylation of ADP-Glucose Pyrophosphorylase During Wheat Seeds Development.Frontiers in plant science · 2020Article
- Early Archean origin of Photosystem II.Geobiology · 2019Article
- Resurrecting the Regulatory Properties of theFrontiers in plant science · 2018Article
- Comparative Analysis of AGPase Genes and Encoded Proteins in Eight Monocots and Three Dicots with Emphasis on Wheat.Frontiers in plant science · 2017Article
- Whole Genome Sequencing Reveals Potential New Targets for Improving Nitrogen Uptake and Utilization inFrontiers in plant science · 2016Article
- Lineage-Specific Evolutionary Histories and Regulation of Major Starch Metabolism Genes during Banana Ripening.Frontiers in plant science · 2016Article
- AGPase: its role in crop productivity with emphasis on heat tolerance in cereals.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2015Review
- Molecular evolution accompanying functional divergence of duplicated genes along the plant starch biosynthesis pathway.BMC evolutionary biology · 2014Article
- The ancestral activation promiscuity of ADP-glucose pyrophosphorylases from oxygenic photosynthetic organisms.BMC evolutionary biology · 2013Article
- Accelerated evolution and coevolution drove the evolutionary history of AGPase sub-units during angiosperm radiation.Annals of botany · 2012Article
- Contrasted patterns of selection since maize domestication on duplicated genes encoding a starch pathway enzyme.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2011Article
- Probing allosteric binding sites of the maize endosperm ADP-glucose pyrophosphorylase.Plant physiology · 2010Article
- Comparison of the starch synthesis genes between maize and rice: copies, chromosome location and expression divergence.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2009Article
- Phylogenetic analysis of ADP-glucose pyrophosphorylase subunits reveals a role of subunit interfaces in the allosteric properties of the enzyme.Plant physiology · 2009Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundADP-glucose pyrophosphorylase (AGPase), which catalyses a rate limiting step in starch synthesis, is a heterotetramer comprised of two identical large and two identical small subunits in plants. Although the large and small subunits are equally sensitive to activity-altering amino acid changes when expressed in a bacterial system, the overall rate of non-synonymous evolution is approximately 2.7-fold greater for the large subunit than for the small subunit. Herein, we examine the basis for their different rates of evolution, the number of duplications in both large and small subunit genes and document changes in the patterns of AGPase evolution over time.
resultsWe found that the first duplication in the AGPase large subunit family occurred early in the history of land plants, while the earliest small subunit duplication occurred after the divergence of monocots and eudicots. The large subunit also had a larger number of gene duplications than did the small subunit. The ancient duplications in the large subunit family raise concern about the saturation of synonymous substitutions, but estimates of the absolute rate of AGPase evolution were highly correlated with estimates of omega (the non-synonymous to synonymous rate ratio). Both subunits showed evidence for positive selection and relaxation of purifying selection after duplication, but these phenomena could not explain the different evolutionary rates of the two subunits. Instead, evolutionary constraints appear to be permanently relaxed for the large subunit relative to the small subunit. Both subunits exhibit branch-specific patterns of rate variation among sites.
conclusionThese analyses indicate that the higher evolutionary rate of the plant AGPase large subunit reflects permanent relaxation of constraints relative to the small subunit and they show that the large subunit genes have undergone more gene duplications than small subunit genes. Candidate sites potentially responsible for functional divergence within each of the AGPase subunits were investigated by examining branch-specific patterns of rate variation. We discuss the phenotypes of mutants that alter some candidate sites and strategies for examining candidate sites of presently unknown function.
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