ArticlePloS one2008
Identification and functional characterization of gene components of Type VI Secretion system in bacterial genomes.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.
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Who cites it
96 citing papers in PubMed, 164 citations in OpenAlex.
- Functional diversity of accessory factors of the type VI secretion system.Journal of bacteriology · 2026Review
- Dynamic and intricate regulation by the Csr sRNAs in the Arctic Pseudoalteromonas fuliginea.Communications biology · 2025Article
- A coordinated attack by a bacterial secretion system and a small molecule drives prey specificity.Communications biology · 2024Article
- Article
- The transcriptome response of Enterobacter sp. S-33 is modulated by low pH-stress.Genes & genomics · 2024Article
- Functionality of chimeric TssA proteins in the type VI secretion system reveals sheath docking specificity within their N-terminal domains.Nature communications · 2024Article
- Unravelling the transcriptome response of Enterobacter sp. S-33 under varying temperature.Archives of microbiology · 2024Article
- Type VI Secretion System Accessory Protein TagAB-5 PromotesBiomedicines · 2023Article
- Early inoculation of an endophyte alters the assembly of bacterial communities across rice plant growth stages.Microbiology spectrum · 2023Article
- Diversity of the type VI secretion systems in theMicrobial genomics · 2023Article
- The Anti-Listeria Activity ofPathogens (Basel, Switzerland) · 2023Article
- Exploring the Microbial Community and Functional Characteristics of the Livestock Feces Using the Whole Metagenome Shotgun Sequencing.Journal of microbiology and biotechnology · 2023Article
- Type VI Secretion Systems: Environmental and Intra-host Competition of Vibrio cholerae.Advances in experimental medicine and biology · 2023Article
- The C-terminal extension of VgrG4 from Klebsiella pneumoniae remodels host cell microfilaments.Proteins · 2022Article
- Genomic Analysis of Prophages fromMicroorganisms · 2021Article
- Comparative Genomics ofMicroorganisms · 2021Article
- The type VI secretion system of Xanthomonas phaseoli pv. manihotis is involved in virulence and in vitro motility.BMC microbiology · 2021Article
- In Silico Characterization of a Hypothetical Protein fromBioinformatics and biology insights · 2021Article
- The Role of ClpB in Bacterial Stress Responses and Virulence.Frontiers in molecular biosciences · 2021Review
- Xanthomonas diversity, virulence and plant-pathogen interactions.Nature reviews. Microbiology · 2020Review
36 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A new secretion system, called the Type VI Secretion system (T6SS), was recently reported in Vibrio cholerae, Pseudomonas aeruginosa and Burkholderia mallei. A total of 18 genes have been identified to be belonging to this secretion system in V. cholerae. Here we attempt to identify presence of T6SS in other bacterial genomes. This includes identification of orthologous sequences, conserved motifs, domains, families, 3D folds, genomic islands containing T6SS components, phylogenetic profiles and protein-protein association of these components. Our analysis indicates presence of T6SS in 42 bacteria and its absence in most of their non-pathogenic species, suggesting the role of T6SS in imparting pathogenicity to an organism. Analysis of genomic regions containing T6SS components, phylogenetic profiles and protein-protein association of T6SS components indicate few additional genes which could be involved in this secretion system. Based on our studies, functional annotations were assigned to most of the components. Except one of the genes, we could group all the other genes of T6SS into those belonging to the puncturing device, and those located in the outer membrane, transmembrane and inner membrane. Based on our analysis, we have proposed a model of T6SS and have compared the same with the other bacterial secretion systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.