ArticleSimulation1999
Discrete-Event Models of Mixed-Phenotype Plasmodium falciparum Malaria.
Article in Simulation, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Dynamics of immune response and drug resistance in malaria infection.Malaria journal · 2006Article
- A biologic basis for integrated malaria control.The American journal of tropical medicine and hygiene · 2002Article
- Meiotic recombination, cross-reactivity, and persistence in Plasmodium falciparum.Evolution; international journal of organic evolution · 2001Article
- SEASONALITY, PARASITE DIVERSITY, AND LOCAL EXTINCTIONS IN PLASMODIUM FALCIPARUM MALARIA.Ecology · 2001Article
- A simplified model for predicting malaria entomologic inoculation rates based on entomologic and parasitologic parameters relevant to control.The American journal of tropical medicine and hygiene · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
We extend our basic discrete-event model of Plasmodium falciparum malaria to encompass circumstances in which multiple phenotypic variants of the parasite circulate within interacting human and mosquito populations, and we compare a version in which variants behave independently to one in which they interact through shared host immune responses. Relative to the standard hypothesis of statistical independence, frequencies of mixed-phenotype infection in humans were as expected in the independent-immunity version and much less than expected in the cross-immunity version; in both versions, however, such frequencies in mosquitoes were much greater than expected.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.