ArticleNeuro-oncology2008
Prevalence of copy-number neutral LOH in glioblastomas revealed by genomewide analysis of laser-microdissected tissues.
Article in Neuro-oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Silencing of ZFP36L2 increases sensitivity to temozolomide through G2/M cell cycle arrest and BAX mediated apoptosis in GBM cells.Molecular biology reports · 2021Pooled it
- Inferring allele-specific copy number aberrations and tumor phylogeography from spatially resolved transcriptomics.Nature methods · 2024Article
- Glioblastoma vaccines: past, present, and opportunities.EBioMedicine · 2024Review
- Characterizing allele- and haplotype-specific copy numbers in single cells with CHISEL.Nature biotechnology · 2021Article
- Review
- Applications of molecular neuro-oncology - a review of diffuse glioma integrated diagnosis and emerging molecular entities.Diagnostic pathology · 2019Review
- hsegHMM: hidden Markov model-based allele-specific copy number alteration analysis accounting for hypersegmentation.BMC bioinformatics · 2018Article
- Prognostic stratification of adult primary glioblastoma multiforme patients based on their tumor gene amplification profiles.Oncotarget · 2018Article
- Cell biology of glioblastoma multiforme: from basic science to diagnosis and treatment.Medical oncology (Northwood, London, England) · 2018Review
- Differences in genetic and epigenetic alterations between von Hippel-Lindau disease-related and sporadic hemangioblastomas of the central nervous system.Neuro-oncology · 2017Article
- Chromosome 17p Homodisomy Is Associated With Better Outcome in 1p19q Non-Codeleted and IDH-Mutated Gliomas.The oncologist · 2016Article
- Article
- Distinct genomic aberrations between low-grade and high-grade gliomas of Chinese patients.PloS one · 2013Article
- Soft tissue sarcoma subtypes exhibit distinct patterns of acquired uniparental disomy.BMC medical genomics · 2012Article
- Parent-specific copy number in paired tumor-normal studies using circular binary segmentation.Bioinformatics (Oxford, England) · 2011Article
- Gone FISHing: clinical lessons learned in brain tumor molecular diagnostics over the last decade.Brain pathology (Zurich, Switzerland) · 2011Review
- Association between acquired uniparental disomy and homozygous mutations and HER2/ER/PR status in breast cancer.PloS one · 2010Article
- Genome wide analysis of DNA copy number neutral loss of heterozygosity (CNNLOH) and its relation to gene expression in esophageal squamous cell carcinoma.BMC genomics · 2010Article
- Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have employed a laser-capture microdissection technique and single-nucleotide polymorphism arrays to characterize genomic alterations associated with the development of glioblastoma multiforme (GBM). Combined analysis of loss of heterozygosity (LOH) and copy number revealed that more than half (56.3%) of the 254 identified LOH loci showed no copy-number alteration, indicating the presence of copy-number neutral LOH (cnLOH). Furthermore, we found a GBM case that showed cnLOH in 18 of the 22 autosomes. These results were confirmed by quantitative real-time PCR, microsatellite analysis, and fluorescence in situ hybridization. The high rate of cnLOH suggests that epigenetic abnormalities of many genes are involved in the development and progression of GBMs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.