ArticleProceedings of the National Academy of Sciences of the United States of America2008
The leaf ionome as a multivariable system to detect a plant's physiological status.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers.
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Who cites it
114 citing papers in PubMed, 311 citations in OpenAlex.
- Fluoride detoxification in tea plants depends on aluminum and localization in the epidermis.Plant physiology · 2026Article
- Divergent Phosphorus-Mining Strategies in Simple and Compound Cluster Roots in Extremely Phosphorus-Impoverished Soils in Southwest Australia.Plant, cell & environment · 2026Article
- Multi-Omics Reveals Domestication-Associated Shifts in Phosphorus Adaptation Strategies in Tomato.Plants (Basel, Switzerland) · 2026Article
- Leaf manganese concentrations reveal phosphorus-mining strategies and trait diversification of Myrtaceae in south-eastern Australia.Annals of botany · 2025Article
- Genetic Variation and Quantitative Trait Loci Analysis of the Maize Ionome in Response to Phosphorus Fertilisation.Plant, cell & environment · 2025Article
- Rapid acquisition of ionomic and morphological data from plant seeds through fast X-ray fluorescence microscopy and computer vision.Plant phenomics (Washington, D.C.) · 2025Article
- Arabidopsis thaliana exhibits wide within-species variation in tolerance to boron limitation and root and shoot trait resilience associate with a pleiotropic locus.The New phytologist · 2025Article
- Iron Solubility and Uptake in Fava Bean and Maize as a Function of Iron Chelates under Alkaline Hydroponic Conditions.Journal of agricultural and food chemistry · 2025Article
- Seasonal Differences in Effects of Microbial Communities on Duckweed Traits.Ecology and evolution · 2025Article
- Influence of different rootstock-interstock-scion combinations on mango (Frontiers in plant science · 2025Article
- Biologically meaningful genome interpretation models to address data underdetermination for the leaf and seed ionome prediction in Arabidopsis thaliana.Scientific reports · 2024Article
- Nutrient and mycoremediation of a global menace 'arsenic': exploring the prospects of phosphorus and Serendipita indica-based mitigation strategies in rice and other crops.Plant cell reports · 2024Review
- Elemental profiling and genome-wide association studies reveal genomic variants modulating ionomic composition inFrontiers in plant science · 2024Article
- Gene regulation and ionome homeostasis in rice plants in response to arsenite stress: potential connection between transcriptomics and ionomics.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Article
- BRUTUS-LIKE (BTSL) E3 ligase-mediated fine-tuning of Fe regulation negatively affects Zn tolerance of Arabidopsis.Journal of experimental botany · 2023Article
- Loss of OPT3 function decreases phloem copper levels and impairs crosstalk between copper and iron homeostasis and shoot-to-root signaling in Arabidopsis thaliana.The Plant cell · 2023Article
- Fast X-ray fluorescence microscopy provides high-throughput phenotyping of element distribution in seeds.Plant physiology · 2023Article
- Silicon modifies leaf nutriome and improves growth of oak seedlings exposed to phosphorus deficiency andFrontiers in plant science · 2023Article
- Silicon in action: Between iron scarcity and excess copper.Frontiers in plant science · 2023Review
- Cadmium alters whole animal ionome and promotes the re-distribution of iron in intestinal cells ofFrontiers in physiology · 2023Article
54 more citing papers are in PubMed but not listed here.
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8 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The contention that quantitative profiles of biomolecules contain information about the physiological state of the organism has motivated a variety of high-throughput molecular profiling experiments. However, unbiased discovery and validation of biomolecular signatures from these experiments remains a challenge. Here we show that the Arabidopsis thaliana (Arabidopsis) leaf ionome, or elemental composition, contains such signatures, and we establish statistical models that connect these multivariable signatures to defined physiological responses, such as iron (Fe) and phosphorus (P) homeostasis. Iron is essential for plant growth and development, but potentially toxic at elevated levels. Because of this, shoot Fe concentrations are tightly regulated and show little variation over a range of Fe concentrations in the environment, making them a poor probe of a plant's Fe status. By evaluating the shoot ionome in plants grown under different Fe nutritional conditions, we have established a multivariable ionomic signature for the Fe response status of Arabidopsis. This signature has been validated against known Fe-response proteins and allows the high-throughput detection of the Fe status of plants with a false negative/positive rate of 18%/16%. A "metascreen" of previously collected ionomic data from 880 Arabidopsis mutants and natural accessions for this Fe response signature successfully identified the known Fe mutants frd1 and frd3. A similar approach has also been taken to identify and use a shoot ionomic signature associated with P homeostasis. This study establishes that multivariable ionomic signatures of physiological states associated with mineral nutrient homeostasis do exist in Arabidopsis and are in principle robust enough to detect specific physiological responses to environmental or genetic perturbations.
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