Evidence map›Paper›PMID 18697862›Full record

ArticleThe Journal of clinical endocrinology and metabolism2008

Prevalence of elevated hemoglobin A1c among patients admitted to the hospital without a diagnosis of diabetes.

Deborah J Wexler, David M Nathan, Richard W Grant, Susan Regan, Allison L Van Leuvan, Enrico Cagliero

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06137963 (Effectiveness of an Augmented Digital Diabetes Prevention Program for Adults With Prediabetes Having Elective Total Hip Arthroplasty), which is not on this map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06137963 nawithdrawnnot on this mapstarted 2024, after this paper: background citation

Effectiveness of an Augmented Digital Diabetes Prevention Program for Adults With Prediabetes Having Elective Total Hip Arthroplasty: A Randomized Control Trial

TypeinterventionalSponsorHospital for Special Surgery, New YorkRan2024 to 2024Enrolled0ConditionsPreDiabetesArmsTransform10 Diabetes Prevention Program
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 92 citations in OpenAlex.

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  19. Perioperative Management of Hyperglycemia and Diabetes in Cardiac Surgery Patients.Endocrinology and metabolism clinics of North America · 2018
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Deborah J WexlerMassachusetts General Hospital Diabetes Center, Bulfinch 408, Massachusetts General Hospital, and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA. dwexler@partners.org
David M Nathan
Richard W Grant
Susan Regan
Allison L Van Leuvan
Enrico Cagliero
Harvard University · USMassachusetts General Hospital · US

Funding

Effective Inpatient Diabetes Management and the Transition to Outpatient CareK23DK080228 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI WEXLER, DEBORAH J · 2007 to 2011
$772k
Overcoming Barriers to Evidence-Based Diabetes CareK23DK067452 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI GRANT, RICHARD W · 2005 to 2009
$653k
NIDDK NIH HHS K23 DK067452NIDDK NIH HHS K23 DK 080 228NIDDK NIH HHS K23 DK080228
6 · The paper itself

Abstract

contextOne in four hospitalized patients has diagnosed diabetes. The prevalence of unrecognized, or undiagnosed, diabetes among hospitalized patients is not well established.

objectiveOur objective was to determine the prevalence of unrecognized probable diabetes in this patient population determined by elevated hemoglobin A1c (HbA1c) level.

designWe conducted a prospective observational cohort trial with retrospective follow-up of patients with elevated HbA1c levels and no diagnosis of diabetes. HbA1c levels were obtained for all patients.

settingThe study was conducted at an acute care general hospital. PATIENTS: Patients included 695 adult, nonobstetric patients admitted on 11 d in 2006.

main outcome measuresOutcome measures included rate of unrecognized probable diabetes, defined as admission HbA1c of more than 6.1% and no diagnosis of diabetes or treatment with antidiabetic medications before or during their admission and rate of unrecognized diabetes 1 yr after discharge.

resultsEighteen percent of hospitalized patients had elevated HbA1c levels without a diagnosis of diabetes. Random glucose levels poorly predicted elevated HbA1c levels (area under receiver operating characteristic curve, 0.60). Neither diagnosed diabetes nor HbA1c level was associated with length of stay or costs (P>0.1 for all comparisons). Only 15% of patients with elevated HbA1c levels who continued to receive care within the system studied had diabetes diagnosed in the year after the index admission.

conclusionsNearly one in five adult patients admitted to a large general hospital had unrecognized probable diabetes, based on elevated HbA1c levels. Random glucose levels during the hospital stay were poorly predictive of this condition. Few hospitalized patients with elevated HbA1c levels were diagnosed within the year after admission.

Indexed as

Glycated HemoglobinInpatientsAdultAgedBlood GlucoseBostonDiabetes MellitusFemaleHospital Bed Capacity, 500 and overHumansMaleMiddle AgedPrevalenceReference ValuesBlood GlucoseGlycated Hemoglobin

Identifiers

PMID18697862
PMCPMC2582564
OpenAlexW2013861903

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.