ArticlePhysiological genomics2008
Effects of in vitro maturation on gene expression in rhesus monkey oocytes.
Article in Physiological genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Dynamic changes in gene expression during human early embryo development: from fundamental aspects to clinical applications.Human reproduction updatePooled it
- Genomic analysis association of tolerance to heat stress in subtropical Egyptian goats Raised in hot dry environment.BMC genomics · 2025Article
- Dysregulation of bisphosphoglycerate mutase during in vitro maturation of oocytes.Journal of assisted reproduction and genetics · 2021Article
- Genotypic divergence in mouse oocyte transcriptomes: possible pathways to hybrid vigor impacting fertility and embryogenesis.Physiological genomics · 2020Article
- Differential gene expression betweenJBRA assisted reproduction · 2019Article
- Disruptions in follicle cell functions in the ovaries of rhesus monkeys during summer.Physiological genomics · 2015Article
- Transgenerational effects of binge drinking in a primate model: implications for human health.Fertility and sterility · 2015Article
- RNA-Seq profiling of single bovine oocyte transcript abundance and its modulation by cytoplasmic polyadenylation.Molecular reproduction and development · 2015Article
- Dietary sugar in healthy female primates perturbs oocyte maturation and in vitro preimplantation embryo development.Endocrinology · 2014Article
- Contribution of CBX4 to cumulus oophorus cell phenotype in mice and attendant effects in cumulus cell cloned embryos.Physiological genomics · 2014Article
- Systems genetics implicates cytoskeletal genes in oocyte control of cloned embryo quality.Genetics · 2013Article
- Variable imprinting of the MEST gene in human preimplantation embryos.European journal of human genetics : EJHG · 2013Article
- Rhesus monkey cumulus cells revert to a mural granulosa cell state after an ovulatory stimulus.Endocrinology · 2012Article
- Early origins of adult disease: approaches for investigating the programmable epigenome in humans, nonhuman primates, and rodents.ILAR journal · 2012Article
- Extensive effects of in vitro oocyte maturation on rhesus monkey cumulus cell transcriptome.American journal of physiology. Endocrinology and metabolism · 2011Article
- Sequential analysis of global gene expression profiles in immature and in vitro matured bovine oocytes: potential molecular markers of oocyte maturation.BMC genomics · 2011Article
- Growth hormone and gene expression of in vitro-matured rhesus macaque oocytes.Molecular reproduction and development · 2010Article
- Differential effects of follistatin on nonhuman primate oocyte maturation and pre-implantation embryo development in vitro.Biology of reproduction · 2009Article
- Oocytes and early embryos selectively express the survival factor BCL2L10.Journal of molecular medicine (Berlin, Germany) · 2009Article
- Role for cumulus cell-produced EGF-like ligands during primate oocyte maturation in vitro.American journal of physiology. Endocrinology and metabolism · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
In vitro oocyte maturation (IVM) holds great promise as a tool for enhancing clinical treatment of infertility, enhancing availability of nonhuman primates for development of disease models, and facilitating endangered species preservation. However, IVM outcomes have remained significantly below the success rates obtained with in vivo matured (VVM) oocytes from humans and nonhuman primates. A cDNA array-based analysis is presented, comparing the transcriptomes of VVM oocytes with IVM oocytes. We observe a small set of just 59 mRNAs that are differentially expressed between the two cell types. These mRNAs are related to cellular homeostasis, cell-cell interactions including growth factor and hormone stimulation and cell adhesion, and other functions such as mRNA stability and translation. Additionally, we observe in IVM oocytes overexpression of PLAGL1 and MEST, two maternally imprinted genes, indicating a possible interruption or loss of correct epigenetic programming. These results indicate that, under certain IVM conditions, oocytes that are molecularly highly similar to VVM oocytes can be obtained; however, the interruption of normal oocyte-somatic cell interactions during the final hours of oocyte maturation may preclude the establishment of full developmental competence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.