ArticleThe Journal of biological chemistry2008
Demosponge and sea anemone fibrillar collagen diversity reveals the early emergence of A/C clades and the maintenance of the modular structure of type V/XI collagens from sponge to human.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 70 citations in OpenAlex.
- Collagen from Marine Sources for Potential Application in Wound Treatment.Progress in molecular and subcellular biology · 2026Review
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- Advances in Molecular Function and Recombinant Expression of Human Collagen.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Flipons and the origin of the genetic code.Biology letters · 2025Article
- Identification of collagen 1α3 in teleost fish species and typical collision induced internal fragmentations.Food chemistry: X · 2022Article
- The Molecular Machinery of Gametogenesis in Geodia Demosponges (Porifera): Evolutionary Origins of a Conserved Toolkit across Animals.Molecular biology and evolution · 2020Article
- Sea Cucumber Derived Type I Collagen: A Comprehensive Review.Marine drugs · 2020Review
- Article
- Evaluation of the Potential of Collagen from Codfish Skin as a Biomaterial for Biomedical Applications.Marine drugs · 2018Article
- Molecular and ultrastructural studies of a fibrillar collagen from octocoral (Cnidaria).The Journal of experimental biology · 2017Article
- Article
- Collagenous Extracellular Matrix Biomaterials for Tissue Engineering: Lessons from the Common Sea Urchin Tissue.International journal of molecular sciences · 2017Review
- Phylogenetic evidence for the modular evolution of metazoan signalling pathways.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Article
- Collagen cross-linking: insights on the evolution of metazoan extracellular matrix.Scientific reports · 2016Article
- Origin and evolution of lysyl oxidases.Scientific reports · 2015Article
- Genomic insights into the marine sponge microbiome.Nature reviews. Microbiology · 2012Review
- The evolution of metazoan extracellular matrix.The Journal of cell biology · 2012Review
- Characterization of tissue-specific and developmentally regulated alternative splicing of exon 64 in the COL5A1 gene.Connective tissue research · 2012Article
- Adaptations to endosymbiosis in a cnidarian-dinoflagellate association: differential gene expression and specific gene duplications.PLoS genetics · 2011Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Collagens are often considered a metazoan hallmark, with the fibril-forming fibrillar collagens present from sponges to human. From evolutionary studies, three fibrillar collagen clades (named A, B, and C) have been defined and shown to be present in mammals, whereas the emergence of the A and B clades predates the protostome/deuterostome split. Moreover, several C clade fibrillar collagen chains are present in some invertebrate deuterostome genomes but not in protostomes whose genomes have been sequenced. The newly sequenced genomes of the choanoflagellate Monosiga brevicollis, the demosponge Amphimedon queenslandica, and the cnidarians Hydra magnipapillata (Hydra) and Nematostella vectensis (sea anemone) allow us to have a better understanding of the origin and evolution of fibrillar collagens. Analysis of these genomes suggests that an ancestral fibrillar collagen gene arose at the dawn of the Metazoa, before the divergence of sponge and eumetazoan lineages. The duplication events leading to the formation of the three fibrillar collagen clades (A, B, and C) occurred before the eumetazoan radiation. Interestingly, only the B clade fibrillar collagens preserved their characteristic modular structure from sponge to human. This observation is compatible with the suggested primordial function of type V/XI fibrillar collagens in the initiation of the formation of the collagen fibrils.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.