ArticleJournal of clinical immunology2009
In vitro differentiation of human monocytes into dendritic cells by peptic-tryptic digest of gliadin is independent of genetic predisposition and the presence of celiac disease.
Article in Journal of clinical immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Immunomodulatory and Anti-Inflammatory Effects of Vitamin A and Tryptophan on Monocyte-Derived Dendritic Cells Stimulated with Gliadin in Celiac Disease Patients.Inflammation · 2024Article
- Effects of CB2 Receptor Modulation on Macrophage Polarization in Pediatric Celiac Disease.Biomedicines · 2022Article
- Intestinal Epithelium Modulates Macrophage Response to Gliadin in Celiac Disease.Frontiers in nutrition · 2019Article
- Dietary Effects on Microbiota-New Trends with Gluten-Free or Paleo Diet.Medical sciences (Basel, Switzerland) · 2018Review
- Recent Advances in Celiac Disease.Indian journal of pediatrics · 2016Review
- Identification and molecular characterization of oat peptides implicated on coeliac immune response.Food & nutrition research · 2016Article
- Matrix expansion and syncytial aggregation of syndecan-1+ cells underpin villous atrophy in coeliac disease.PloS one · 2014Article
- Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4.The Journal of experimental medicine · 2012Article
- Maize prolamins resistant to peptic-tryptic digestion maintain immune-recognition by IgA from some celiac disease patients.Plant foods for human nutrition (Dordrecht, Netherlands) · 2012Article
- Rapid accumulation of CD14+CD11c+ dendritic cells in gut mucosa of celiac disease after in vivo gluten challenge.PloS one · 2012Article
- Gliadin fragments promote migration of dendritic cells.Journal of cellular and molecular medicine · 2011Article
- Monocytes differentiated with IL-15 support Th17 and Th1 responses to wheat gliadin: implications for celiac disease.Clinical immunology (Orlando, Fla.) · 2010Article
- Dendritic cells in intestinal homeostasis and disease.The Journal of clinical investigation · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis study was done to further reveal the role of the innate immune system in celiac disease.
methodsDendritic cells were matured from venous blood of patients with active or treated celiac disease and DQ2-DQ8-positive or negative controls. Dendritic cells were treated with a peptic-tryptic digest of gliadin (500 microg/ml) and their activation was analyzed by fluorescent-activated cell sorting analysis, cytokine secretion, and their ability to elicit T cell proliferation. RESULTS AND DISCUSSION: Gliadin upregulated interleukin (IL)-6, IL-8, and IL-12 (p40) secretion in dendritic cells and induced strong expression of the maturation markers human leukocyte antigen (HLA)-DR, CD25, CD83, and CD86 of all subjects irrespective of their genotype or the presence of disease, whereas the digest of bovine serum albumin showed no effect. However, gliadin-stimulated dendritic cells from active celiac showed enhanced stimulation of autologous T cells compared to the other groups.
conclusionFurther research should be aimed at identifying the mechanisms that control inflammation in healthy individuals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.