ReviewInvertebrate neuroscience : IN2008
Insect ryanodine receptors: molecular targets for novel pest control chemicals.
Review in Invertebrate neuroscience : IN, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 415 citations in OpenAlex.
- Biochemical and molecular responses of Spodoptera frugiperda to insecticide exposure: detoxification enzymes, gene expression, and genotoxic effects.Scientific reports · 2026Article
- Computational Discovery of NPA001937: A Novel Carotenoid Targeting Conserved Insect Proteins for Sustainable Pest Management.Applied biochemistry and biotechnology · 2026Article
- Molecular Insights into the Action Mechanism, Resistance Development, and Ecological Risks of Cyantraniliprole.International journal of molecular sciences · 2026Review
- Whole-genome sequencing reveals novel ryanodine receptor mutations P4568L and Y4701D conferring high-level chlorantraniliprole resistance in Spodoptera litura (Lepidoptera: Noctuidae).Pest management science · 2026Article
- Quantitative genetic analysis of diamide resistance in Australian Spodoptera litura (Fabricius) (Lepidoptera: Noctuidae).Scientific reports · 2025Article
- Two-way transcriptome approach for the identification of common gene targets across four insect orders and its validation in Oxycarenus laetus.Scientific reports · 2025Article
- The Evolution of Pesticide Resistance: A Data-Driven Case Study of Chlorantraniliprole Resistance inEvolutionary applications · 2025Review
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- Article
- No impact of cyantraniliprole on the hibernation success of bumble bees (Ecology and evolution · 2024Article
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- Synthesis and Insecticidal Activity of Novel Anthranilic Diamide Insecticides Containing Indane and Its Analogs.International journal of molecular sciences · 2024Article
- Molecular Docking of Nimbolide Extracted from Leaves ofIndian journal of microbiology · 2023Article
- The modes of action of ion-channel-targeting neurotoxic insecticides: lessons from structural biology.Nature structural & molecular biology · 2023Review
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- The effect of chlorantraniliprole on the transcriptomic profile of Spodoptera frugiperda: a typical case analysis for the response of a newly invaded pest to an old insecticide.Molecular biology reports · 2023Article
- The Comparative Toxicity, Biochemical and Physiological Impacts of Chlorantraniliprole and Indoxacarb onToxics · 2023Article
- Effects of chlorantraniliprole on the life history traits of fall armywormFrontiers in physiology · 2023Article
- Transcriptome of the pygmy grasshopperPeerJ · 2023Article
- Functional Characterization of the Ryanodine Receptor Gene inLife (Basel, Switzerland) · 2022Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Ryanodine receptors (RyRs) are a distinct class of ligand-gated calcium channels controlling the release of calcium from intracellular stores. They are located on the sarcoplasmic reticulum of muscle and the endoplasmic reticulum of neurons and many other cell types. Ryanodine, a plant alkaloid and an important ligand used to characterize and purify the receptor, has served as a natural botanical insecticide, but attempts to generate synthetic commercial analogues of ryanodine have proved unsuccessful. Recently two classes of synthetic chemicals have emerged resulting in commercial insecticides that target insect RyRs. The phthalic acid diamide class has yielded flubendiamide, the first synthetic ryanodine receptor insecticide to be commercialized. Shortly after the discovery of the phthalic diamides, the anthranilic diamides were discovered. This class has produced the insecticides Rynaxypyr and Cyazypyr. Here we review the structure and functions of insect RyRs and address the modes of action of phthalic acid diamides and anthranilic diamides on insect ryanodine receptors. Particularly intersting is the inherent selectivity both chemical classes exhibit for insect RyRs over their mammalian counterparts. The future prospects for RyRs as a commercially-validated target site for insect control chemicals are also considered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.