ArticlePediatric nephrology (Berlin, Germany)2009
Erythropoietin dosing in children with chronic kidney disease: based on body size or on hemoglobin deficit?
Article in Pediatric nephrology (Berlin, Germany), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Real-world evidence on the dosing and safety of C.E.R.A. in pediatric dialysis patients: findings from the International Pediatric Dialysis Network registries.Pediatric nephrology (Berlin, Germany) · 2024Article
- Anemia in chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2018Review
- Chronic kidney disease in children.Clinical kidney journal · 2016Article
- Association of higher erythropoiesis stimulating agent dose and mortality in children on dialysis.Pediatric nephrology (Berlin, Germany) · 2014Article
- Management of anemia with erythropoietic-stimulating agents in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2014Review
- Resistance to erythropoietin-stimulating agents: etiology, evaluation, and therapeutic considerations.Pediatric nephrology (Berlin, Germany) · 2012Review
- Dosing of glucocorticosteroids in nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2011Article
- Anemia in children with chronic kidney disease.Nature reviews. Nephrology · 2011Review
- No difference in meeting hemoglobin and albumin targets for dialyzed children with urologic disorders.Pediatric nephrology (Berlin, Germany) · 2011Article
- Risk for anemia in pediatric chronic kidney disease patients: a report of NAPRTCS.Pediatric nephrology (Berlin, Germany) · 2010Article
- Target hemoglobin trials in chronic kidney disease: design and interpretation issues.Pediatric nephrology (Berlin, Germany) · 2009Review
Corrections and comments
- Comment on
- Erratum issued
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are no investigations demonstrating that body size-adapted doses of erythropoietin (EPO) are as equally effective in children as in adults. A treatment starting with 150 IU/kg body weight per week leads to an insufficient rise in hemoglobin levels in anemic children with chronic kidney disease (CKD). Nevertheless, this strategy is widely used and seems to be the reason for a high percentage of young anemic children in spite of EPO treatment. In children and in adults, 1,000 IU EPO intravenously increases the hemoglobin level equally by 0.04 g/l. This strongly argues for specifying the EPO dose in the treatment of children with CKD in absolute amounts. A prediction model exists which allows the determination of the EPO dose which is expected to raise hemoglobin from a given pretreatment level to a desired steady state level.
Indexed as
Identifiers
18696118What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.