ArticleHistochemistry and cell biology2008
All Trypanosoma cruzi developmental forms present lysosome-related organelles.
Article in Histochemistry and cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 59 citations in OpenAlex.
- A PQQ-dependent oxidoreductase inFrontiers in cellular and infection microbiology · 2026Article
- Lysosome and plasma membrane Piezo channels of Trypanosoma cruzi are essential for proliferation, differentiation and infectivity.PLoS pathogens · 2025Article
- A versatile 2A peptide-based strategy for ectopic expression and endogenous gene tagging inHeliyon · 2024Article
- Transcriptomic analysis of the adaptation to prolonged starvation of the insect-dwellingFrontiers in cellular and infection microbiology · 2023Article
- Lysosome assembly and disassembly changes endocytosis rate through the Leishmania cell cycle.MicrobiologyOpen · 2020Article
- Detection of Weakly Expressed Trypanosoma cruzi Membrane Proteins Using High-Performance Probes.The Journal of eukaryotic microbiology · 2018Article
- Trypanosoma cruzi serinecarboxipeptidase is a sulfated glycoprotein and a minor antigen in human Chagas disease infection.Medical microbiology and immunology · 2018Article
- Novel scaffolds for inhibition of Cruzipain identified from high-throughput screening of anti-kinetoplastid chemical boxes.Scientific reports · 2017Article
- Cloning and characterization of the first serine carboxypeptidase from a plant parasitic nematode, Radopholus similis.Scientific reports · 2017Article
- Article
- Interactions between 4-aminoquinoline and heme: Promising mechanism against Trypanosoma cruzi.International journal for parasitology. Drugs and drug resistance · 2016Article
- RNA-binding proteins related to stress response and differentiation in protozoa.World journal of biological chemistry · 2016Review
- Phylogenetic and morphological characterization of trypanosomes from Brazilian armoured catfishes and leeches reveal high species diversity, mixed infections and a new fish trypanosome species.Parasites & vectors · 2015Article
- A Novel Trypanosoma cruzi Protein Associated to the Flagellar Pocket of Replicative Stages and Involved in Parasite Growth.PloS one · 2015Article
- Article
- Golgi UDP-GlcNAc:polypeptide O-α-N-Acetyl-d-glucosaminyltransferase 2 (TcOGNT2) regulates trypomastigote production and function in Trypanosoma cruzi.Eukaryotic cell · 2014Article
- Expression and cellular trafficking of GP82 and GP90 glycoproteins during Trypanosoma cruzi metacyclogenesis.Parasites & vectors · 2013Article
- Trypanosoma cruzi response to sterol biosynthesis inhibitors: morphophysiological alterations leading to cell death.PloS one · 2013Article
- On the ultrastructural organization of Trypanosoma cruzi using cryopreparation methods and electron tomography.Histochemistry and cell biology · 2012Article
- Interactive multimedia to teach the life cycle of Trypanosoma cruzi, the causative agent of Chagas disease.PLoS neglected tropical diseases · 2012Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trypanosoma cruzi epimastigote forms concentrate their major protease, cruzipain, in the same compartment where these parasites store macromolecules obtained from medium and for this ability these organelles were named as reservosomes. Intracellular digestion occurs mainly inside reservosomes and seems to be modulated by cruzipain and its natural inhibitor chagasin that also concentrates in reservosomes. T. cruzi mammalian forms, trypomastigotes and amastigotes, are unable to capture macromolecules by endocytosis, but also express cruzipain and chagasin, whose role in infectivity has been described. In this paper, we demonstrate that trypomastigotes and amastigotes also concentrate cruzipain, chagasin as well as serine carboxypeptidase in hydrolase-rich compartments of acidic nature. The presence of P-type proton ATPase indicates that this compartment is acidified by the same enzyme as epimastigote endocytic compartments. Electron microscopy analyzes showed that these organelles are placed at the posterior region of the parasite body, are single membrane bound and possess an electron-dense matrix with electronlucent inclusions. Three-dimensional reconstruction showed that these compartments have different size and shape in trypomastigotes and amastigotes. Based on these evidences, we suggest that all T. cruzi developmental stages present lysosome-related organelles that in epimastigotes have the additional and unique ability of storing cargo.
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