ArticleClinical research in cardiology : official journal of the German Cardiac Society2008
The initial slope of the VCO2/VO2-curve (s1) in cardiopulmonary exercise testing is a strong and independent predictor of outcome in patients with previous myocardial infarction.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- BNP and NT-proBNP as prognostic markers in persons with chronic stable heart failure.Heart failure reviews · 2014Pooled it
- Leukocyte telomere length and left ventricular function after acute ST-elevation myocardial infarction: data from the glycometabolic intervention as adjunct to primary coronary intervention in ST elevation myocardial infarction (GIPS-III) trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Trial
- Review
- Predictive role of peak VOHerz · 2025Article
- Power Output and Efficiency During Supine, Recumbent, and Upright Cycle Ergometry.Frontiers in sports and active living · 2021Article
- Different outcomes of a cardiac rehabilitation programme in functional parameters among myocardial infarction survivors according to ejection fraction.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2019Article
- Impact of intracoronary reinfusion of bone marrow-derived mononuclear progenitor cells on cardiopulmonary exercise capacity in patients with chronic postinfarction heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2013Article
- Soluble TWEAK predicts hemodynamic impairment and functional capacity in patients with pulmonary arterial hypertension.Clinical research in cardiology : official journal of the German Cardiac Society · 2011Article
- Prevalence of ventricular discordance and its relation to functional capacity in idiopathic dilated cardiomyopathy.Clinical research in cardiology : official journal of the German Cardiac Society · 2009Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDetecting heart failure (HF) patients at risk is a relevant clinical problem. Our goal was to define associations of clinical HF-markers and exercise parameters with respect to their prognostic power in HF-patients.
methodsWe performed cardiopulmonary exercise testing (CPET) in 103 ischemic HF-patients. CPET-parameters included peak VO(2), VO(2) at AT, peak oxygen pulse, minimal CO(2) and O(2) equivalents, VE/VCO(2) and s1, a motivation-independent and submaximal parameter representing the initial slope of the VCO(2)/VO(2)-curve that has not been described in HF-patients so far.
resultsMedian follow-up was 668 days. The combined endpoint of cardiovascular death and rehospitalization due to HF occurred in 14 patients. Patients with/without events differed significantly regarding their age, NYHA-class, LVEF and NT-proBNP serum-levels. Patients with events had significantly lower peak VO(2)- and higher s1-values. NT-proBNP serum-levels, NYHA-class and LVEF were significantly correlated with peak VO(2). Only age, peak VO(2) and s1 were independent predictors of adverse events. Using multivariate analysis, s1 was a strong and independent parameter with good sensitivity and specificity.
conclusions1 is an independent and powerful predictor in HF-patients. Since s1 is independent of maximal exercise capacity, s1 might be more accurate for the evaluation of HF-patients not willing or unable to perform maximal exercise.
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