ArticleGenetica2009
Patterns of quantitative genetic variation in multiple dimensions.
Article in Genetica, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
72 citing papers in PubMed.
- Adaptation to seasonal drought in Arabis alpina is linked to the demographic history and climatic changes since the last glacial maximum.Molecular biology and evolution · 2026Article
- Persistent selection on size explains micro- and macroevolutionary alignments in fly wings.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Genetic Evaluation Weight, Carcass and Stayability in Nellore Females.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2025Article
- The Price Equation Reveals a Universal Force-Metric-Bias Law of Algorithmic Learning and Natural Selection.Entropy (Basel, Switzerland) · 2025Article
- On the resolution of sexual conflict over shared traits.Proceedings. Biological sciences · 2024Review
- Drift on holey landscapes as a dominant evolutionary process.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Two common, often coexisting grassland plant species differ in their evolutionary potential in response to experimental drought.Ecology and evolution · 2023Article
- Article
- A genetic tradeoff for tolerance to moderate and severe heat stress in US hybrid maize.PLoS genetics · 2023Article
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- Diversity in nonlinear responses to soil moisture shapes evolutionary constraints in Brachypodium.G3 (Bethesda, Md.) · 2021Article
- Mapping pleiotropic loci using a fast-sequential testing algorithm.European journal of human genetics : EJHG · 2021Article
- Integrating genomics and multivariate evolutionary quantitative genetics: a case study of constraints on sexual selection inProceedings. Biological sciences · 2021Article
- The contribution of mutation and selection to multivariate quantitative genetic variance in an outbred population ofProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Immigration counter-acts local micro-evolution of a major fitness component: Migration-selection balance in free-living song sparrows.Evolution letters · 2021Article
- Genetic basis for divergence in developmental gene expression in two closely related sea urchins.Nature ecology & evolution · 2020Article
- Why does allometry evolve so slowly?Integrative and comparative biology · 2019Article
- EIGENVALUE DISTRIBUTIONS OF VARIANCE COMPONENTS ESTIMATORS IN HIGH-DIMENSIONAL RANDOM EFFECTS MODELS.Annals of statistics · 2019Article
- Causes of maladaptation.Evolutionary applications · 2019Review
- Sexual antagonism drives the displacement of polymorphism across gene regulatory cascades.Proceedings. Biological sciences · 2019Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A fundamental question for both evolutionary biologists and breeders is the extent to which genetic correlations limit the ability of populations to respond to selection. Here I view this topic from three perspectives. First, I propose several nondimensional statistics to quantify the genetic variation present in a suite of traits and to describe the extent to which correlations limit their selection response. A review of five data sets suggests that the total variation differs substantially between populations. In all cases analyzed, however, the "effective number of dimensions" is less than two: more than half of the total genetic variation is explained by a single combination of traits. Second, I consider how patterns of variation affect the average evolutionary response to selection in a random direction. When genetic variation lies in a small number of dimensions but there are a large number of traits under selection, then the average selection response will be reduced substantially from its potential maximum. Third, I discuss how a low genetic correlation between male fitness and female fitness limits the ability of populations to adapt. Data from two recent studies of natural populations suggest this correlation can diminish or even erase any genetic benefit to mate choice. Together these results suggest that adaptation (in natural populations) and genetic improvement (in domesticated populations) may often be as much constrained by patterns of genetic correlation as by the overall amount of genetic variation.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.