ArticleInternational journal of medical sciences2008
Significant association between Helicobacter pylori infection and serum C-reactive protein.
Article in International journal of medical sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- The effect of Hp infection on dyslipidemia in Asia and out of Asia: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Helicobacter pylori seroprevalence and its association with prevalent and incident blood pressure and haemoglobin A1c in the US-based National Longitudinal Study of Adolescent to Adult Health.BMJ public health · 2026Article
- The association between red blood cell distribution width-to-albumin ratio andFrontiers in nutrition · 2026Article
- Helicobacter pylori in the Philippines: Social and Ecological Determinants of Seropositivity and Lack of Association With Systemic Inflammation.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Protein Biomarkers of Gastric Preneoplasia and Cancer Lesions in Blood: A Comprehensive Review.Cancers · 2024Review
- C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians.Diseases (Basel, Switzerland) · 2023Review
- Lacticaseibacillus casei T1 attenuates Helicobacter pylori-induced inflammation and gut microbiota disorders in mice.BMC microbiology · 2023Article
- The association ofHeliyon · 2022Article
- Association betweenFrontiers in endocrinology · 2022Article
- Evaluation of Lipid Profile and Inflammatory Marker in Patients with GastricInternational journal of general medicine · 2022Article
- Use of Fourier-Transform Infrared Spectroscopy (FT-IR) for Monitoring ExperimentalInternational journal of molecular sciences · 2020Article
- Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review).Journal of clinical medicine · 2020Review
- Association of active Helicobacter pylori infection and anemia in elderly males.BMC infectious diseases · 2019Article
- Lack of Association betweenThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2018Article
- Comparison of gastric juice soluble triggering receptor expressed on myeloid cells and C-reactive protein for detection ofElectronic physician · 2017Article
- Review
- Serum hsCRP and procalcitonin levels in dyspeptic patients infected with CagA-positive Helicobacter pylori.Journal of clinical laboratory analysis · 2015Article
- The effect of simple imputation on inferences about population means when data are missing in biomedical research due to detection limits.Shanghai archives of psychiatry · 2015Article
- Helicobacter pylori gastritis, a presequeale to coronary plaque.Clinics and practice · 2015Article
- A comparative study of broccoli sprouts powder and standard triple therapy on cardiovascular risk factors following H.pylori eradication: a randomized clinical trial in patients with type 2 diabetes.Journal of diabetes and metabolic disorders · 2014Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHelicobacter pylori (H. pylori) infection in gastric mucosa may cause systemic inflammatory reaction. This study aimed to examine the association between the infection and serum high sensitivity C-reactive protein (hsCRP).
methodsSubjects were comprised of three groups; 453 health checkup examinees from Yakumo town inhabitants in Hokkaido, Japan (YTI, 153 males and 300 females), 449 health checkup examinees (ENUH, 273 males and 176 females), and 255 female patients of an infertility clinic (PIC), Nagoya University Hospital. Twenty participants with hsCRP more than 1 mg/dl were excluded from the analysis. Those with hsCRP more than 0.1mg/dl were defined as high hsCRP individuals. H. pylori infection status was examined with a serum IgG antibody test.
resultsWhen the three groups were combined, the geometric mean of hsCRP concentration was significantly higher among the seropositives (0.047 mg/dl) than among the seronegatives (0.035 mg/dl); p<0.0001 by a t-test. The percentage of high hsCRP individuals was also higher in the seropositives than in the seronegatives among any group; 23.3% and 20.1% in YTI, 22.0% and 16.0% in ENUH, and 32.7% and 18.7% in PIC, respectively, although the difference was significant only in ENUH. The summary odds ratio of the high hsCRP for the seropositives relative to the seronegatives was 1.38 (95% confidence interval, 1.01-1.89), when age, sex, body mass index, smoking, and subject group were adjusted by a logistic model.
conclusionsIn three groups, hsCRP was higher among the infected individuals. The summary odd ratio indicated that H. pylori infection could influence the serum hsCRP level.
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