ArticleThe Journal of cell biology2008
Protection of specific maternal messenger RNAs by the P body protein CGH-1 (Dhh1/RCK) during Caenorhabditis elegans oogenesis.
Article in The Journal of cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
81 citing papers in PubMed, 115 citations in OpenAlex.
- GLA-3 mediates the heat shock response in Caenorhabditis elegans germ cells: A key role for the tristetraprolin (TTP) family.PloS one · 2026Article
- Germ granule-mediated mRNA storage and translational control.RNA biology · 2025Review
- Article
- Two eIF4E paralogs occupy separate germ granule messenger ribonucleoproteins that mediate mRNA repression and translational activation.Genetics · 2025Article
- The molecular mechanisms underpinning maternal mRNA dormancy.Biochemical Society transactions · 2024Review
- P-body-like condensates in the germline.Seminars in cell & developmental biology · 2024Review
- Eukaryotic mRNA decapping factors: molecular mechanisms and activity.The FEBS journal · 2023Review
- Towards understanding centriole elimination.Open biology · 2023Review
- Condensate cooperativity underlies transgenerational gene silencing.Cell reports · 2023Article
- RNA Helicase DDX6 Regulates A-to-I Editing and Neuronal Differentiation in Human Cells.International journal of molecular sciences · 2023Article
- Specialized germline P-bodies are required to specify germ cell fate in Caenorhabditis elegans embryos.Development (Cambridge, England) · 2022Article
- Germ Granules in Animal Oogenesis.Journal of developmental biology · 2022Review
- Eukaryotic mRNA Decapping Activation.Frontiers in genetics · 2022Review
- A PutativeFrontiers in cell and developmental biology · 2022Article
- Insight into the interaction between the RNA helicase CGH-1 and EDC-3 and its implications.Scientific reports · 2021Article
- The ATXN2 OrthologsInternational journal of molecular sciences · 2021Article
- Phase Separation in Germ Cells and Development.Developmental cell · 2020Review
- DHH1/DDX6-like RNA helicases maintain ephemeral half-lives of stress-response mRNAs.Nature plants · 2020Article
- Recruitment of mRNAs to P granules by condensation with intrinsically-disordered proteins.eLife · 2020Article
- Reduction of mRNA export unmasks different tissue sensitivities to low mRNA levels during Caenorhabditis elegans development.PLoS genetics · 2019Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
During oogenesis, numerous messenger RNAs (mRNAs) are maintained in a translationally silenced state. In eukaryotic cells, various translation inhibition and mRNA degradation mechanisms congregate in cytoplasmic processing bodies (P bodies). The P body protein Dhh1 inhibits translation and promotes decapping-mediated mRNA decay together with Pat1 in yeast, and has been implicated in mRNA storage in metazoan oocytes. Here, we have investigated in Caenorhabditis elegans whether Dhh1 and Pat1 generally function together, and how they influence mRNA sequestration during oogenesis. We show that in somatic tissues, the Dhh1 orthologue (CGH-1) forms Pat1 (patr-1)-dependent P bodies that are involved in mRNA decapping. In contrast, during oogenesis, CGH-1 forms patr-1-independent mRNA storage bodies. CGH-1 then associates with translational regulators and a specific set of maternal mRNAs, and prevents those mRNAs from being degraded. Our results identify somatic and germ cell CGH-1 functions that are distinguished by the involvement of PATR-1, and reveal that during oogenesis, numerous translationally regulated mRNAs are specifically protected by a CGH-1-dependent mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.