ArticleThe Journal of cell biology2008
dLKR/SDH regulates hormone-mediated histone arginine methylation and transcription of cell death genes.
Article in The Journal of cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Homocysteine and S-adenosyl-L-homocysteine impair development and methylation in yeast and flies.Disease models & mechanisms · 2026Article
- LKRSDH-dependent histone modifications of insulin-like peptide sites contribute to age-related circadian rhythm changes.Nature communications · 2024Article
- The Dynamic and Crucial Role of the Arginine Methylproteome in Myoblast Cell Differentiation.International journal of molecular sciences · 2023Article
- A comparative proteomic approach using metabolic pathways for the identification of potential drug targets against Helicobacter pylori.Genes & genomics · 2020Article
- Autophagy-dependent cell death.Cell death and differentiation · 2019Review
- Metabolomic Analysis Reveals That theGenetics · 2017Article
- Wound healing, calcium signaling, and other novel pathways are associated with the formation of butterfly eyespots.BMC genomics · 2017Article
- Chemical Isotope Labeling LC-MS for Monitoring Disease Progression and Treatment in Animal Models: Plasma Metabolomics Study of Osteoarthritis Rat Model.Scientific reports · 2017Article
- Effects of temperature on transcriptome and cuticular hydrocarbon expression in ecologically differentiated populations of desertEcology and evolution · 2017Article
- Cell death in development: Signaling pathways and core mechanisms.Seminars in cell & developmental biology · 2015Review
- Article
- Cell lines.Methods (San Diego, Calif.) · 2014Review
- UTX coordinates steroid hormone-mediated autophagy and cell death.Nature communications · 2013Article
- Metabolomic profiling reveals that Drosophila melanogaster larvae with the y mutation have altered lysine metabolism.FEBS open bio · 2012Article
- Structural and transcriptional analysis of plant genes encoding the bifunctional lysine ketoglutarate reductase saccharopine dehydrogenase enzyme.BMC plant biology · 2010Article
- Autophagy, not apoptosis, is essential for midgut cell death in Drosophila.Current biology : CB · 2009Article
- LKR/SDH plays important roles throughout the tick life cycle including a long starvation period.PloS one · 2009Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sequential modifications of histones form the basis of the histone code that translates into either gene activation or repression. Nuclear receptors recruit a cohort of histone-modifying enzymes in response to ligand binding and regulate proliferation, differentiation, and cell death. In Drosophila melanogaster, the steroid hormone ecdysone binds its heterodimeric receptor ecdysone receptor/ultraspiracle to spatiotemporally regulate the transcription of several genes. In this study, we identify a novel cofactor, Drosophila lysine ketoglutarate reductase (dLKR)/saccharopine dehydrogenase (SDH), that is involved in ecdysone-mediated transcription. dLKR/SDH binds histones H3 and H4 and suppresses ecdysone-mediated transcription of cell death genes by inhibiting histone H3R17me2 mediated by the Drosophila arginine methyl transferase CARMER. Our data suggest that the dynamic recruitment of dLKR/SDH to ecdysone-regulated gene promoters controls the timing of hormone-induced gene expression. In the absence of dLKR/SDH, histone methylation occurs prematurely, resulting in enhanced gene activation. Consistent with these observations, the loss of dLKR/SDH in Drosophila enhances hormone-regulated gene expression, affecting the developmental timing of gene activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.