ArticleDiabetes care2008
Association between maternal diabetes in utero and age at offspring's diagnosis of type 2 diabetes.
Article in Diabetes care, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Risk factors of early-onset type 2 diabetes: A systematic review and meta-analysis.Diabetes & vascular disease researchPooled it
- Relationship Between Parental Diabetes and Presentation of Metabolic and Glycemic Function in Youth With Type 2 Diabetes: Baseline Findings From the TODAY Trial.Diabetes care · 2016 · on this mapTrial
- Characteristics of adolescents and youth with recent-onset type 2 diabetes: the TODAY cohort at baseline.The Journal of clinical endocrinology and metabolism · 2011 · on this mapTrial
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- Dad's Diet Shapes the Future: How Paternal Nutrition Impacts Placental Development and Childhood Metabolic Health.Molecular nutrition & food research · 2025Review
- Young-onset type 2 diabetes-Epidemiology, pathophysiology, and management.Journal of diabetes investigation · 2025Review
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- Early onset type 2 diabetes mellitus: an update.Endocrine · 2024Review
- Young-Onset Diabetes in East Asians: From Epidemiology to Precision Medicine.Endocrinology and metabolism (Seoul, Korea) · 2024Review
- Less common forms of diabetes in young population.Pediatric endocrinology, diabetes, and metabolism · 2024Review
- Maternal Diabetes in Youth-Onset Type 2 Diabetes Is Associated With Progressive Dysglycemia and Risk of Complications.The Journal of clinical endocrinology and metabolism · 2023Article
- A novel technique using chronic infusion of small extracellular vesicles from gestational diabetes mellitus causes glucose intolerance in pregnant mice.Clinical science (London, England : 1979) · 2022Article
- Developmental origins of adult diseases.Medical review (2021) · 2022Review
- Immunometabolic adaptation and immune plasticity in pregnancy and the bi-directional effects of obesity.Clinical and experimental immunology · 2022Article
- Circulating extracellular vesicles exhibit a differential miRNA profile in gestational diabetes mellitus pregnancies.PloS one · 2022Article
- Review
- Twenty years of pediatric diabetes surveillance: what do we know and why it matters.Annals of the New York Academy of Sciences · 2021Review
- Maternal health and non-communicable disease prevention: An investment case for the post COVID-19 world and need for better health economic data.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2020Article
- Developmental Programming of Body Composition: Update on Evidence and Mechanisms.Current diabetes reports · 2019Review
- Feasibility of a family-focused YMCA-based diabetes prevention program in youth: The E.P.I.C. Kids (Encourage, Practice, and Inspire Change) Study.Preventive medicine reports · 2019Article
Corrections and comments
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Authors and funding
12 authors at 12 institutions in 1 country.
Funding
Abstract
objectiveThe purpose of this study was to examine age of diabetes diagnosis in youth who have a parent with diabetes by diabetes type and whether the parent's diabetes was diagnosed before or after the youth's birth. RESEARCH DESIGN AND
methodsThe cohort comprised SEARCH for Diabetes in Youth Study participants (diabetes diagnosis 2001-2005) with a diabetic parent. SEARCH is a multicenter survey of youth with diabetes diagnosed before age 20 years.
resultsYouth with type 2 diabetes were more likely to have a parent with either type 1 or type 2 diabetes (mother 39.3%; father 21.2%) than youth with type 1 diabetes (5.3 and 6.7%, respectively, P < 0.001 for each). Type 2 diabetes was diagnosed 1.68 years earlier among those exposed to diabetes in utero (n = 174) than among those whose mothers' diabetes was diagnosed later (P = 0.018, controlled for maternal diagnosis age, paternal diabetes, sex, and race/ethnicity). Age at diagnosis of type 1 diabetes for 269 youth with and without in utero exposure did not differ significantly (difference 0.96 year, P = 0.403 after adjustment). Controlled for the father's age of diagnosis, father's diabetes before the child's birth was not associated with age at diagnosis (P = 0.078 for type 1 diabetes; P = 0.140 for type 2 diabetes).
conclusionsType 2 diabetes was diagnosed at younger ages among those exposed to hyperglycemia in utero. Among youth with type 1 diabetes, the effect of the intrauterine exposure was not significant when controlled for mother's age of diagnosis. This study helps explain why other studies have found higher age-specific rates of type 2 diabetes among offspring of women with diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.