ArticleMolecular and cellular biology2008
Drosophila ATF-2 regulates sleep and locomotor activity in pacemaker neurons.
Article in Molecular and cellular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Sleep regulation inFrontiers in neuroscience · 2026Review
- Review
- Guarana improves behavior and inflammatory alterations triggered by methylmercury exposure: an in vivo fruit fly and in vitro neural cells study.Environmental science and pollution research international · 2019Article
- Article
- Ethoscopes: An open platform for high-throughput ethomics.PLoS biology · 2017Article
- Effects of Kamikihito and Unkei-to on Sleep Behavior of Wild Type and Parkinson Model inFrontiers in psychiatry · 2017Article
- Article
- Caste-specific RNA editomes in the leaf-cutting ant Acromyrmex echinatior.Nature communications · 2014Article
- Electrical activity can impose time of day on the circadian transcriptome of pacemaker neurons.Current biology : CB · 2012Article
- Video tracking and analysis of sleep in Drosophila melanogaster.Nature protocols · 2012Article
- Inheritance and memory of stress-induced epigenome change: roles played by the ATF-2 family of transcription factors.Genes to cells : devoted to molecular & cellular mechanisms · 2012Review
- Genetics of sleep and sleep disorders.Cell · 2011Review
- Non-mammalian genetic model systems in sleep research.Sleep medicine clinics · 2011Article
- Transcriptional control of behavior: engrailed knock-out changes cockroach escape trajectories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- The GABA(A) receptor RDL acts in peptidergic PDF neurons to promote sleep in Drosophila.Current biology : CB · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stress-activated protein kinases such as p38 regulate the activity of transcription factor ATF-2. However, the physiological role of ATF-2, especially in the brain, is unknown. Here, we found that Drosophila melanogaster ATF-2 (dATF-2) is expressed in large ventral lateral neurons (l-LN(v)s) and also, to a much lesser extent, in small ventral lateral neurons, the pacemaker neurons. Only l-LN(v)s were stained with the antibody that specifically recognizes phosphorylated dATF-2, suggesting that dATF-2 is activated specifically in l-LN(v)s. The knockdown of dATF-2 in pacemaker neurons using RNA interference decreased sleep time, whereas the ectopic expression of dATF-2 increased sleep time. dATF-2 knockdown decreased the length of sleep bouts but not the number of bouts. The ATF-2 level also affected the sleep rebound after sleep deprivation and the arousal threshold. dATF-2 negatively regulated locomotor activity, although it did not affect the circadian locomotor rhythm. The degree of dATF-2 phosphorylation was greater in the morning than at night and was enhanced by forced locomotion via the dp38 pathway. Thus, dATF-2 is activated by the locomotor while it increases sleep, suggesting a role for dATF-2 as a regulator to connect sleep with locomotion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.