ReviewNeuropharmacology2009
Drosophila, a genetic model system to study cocaine-related behaviors: a review with focus on LIM-only proteins.
Review in Neuropharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 57 citations in OpenAlex.
- Bitter Sensing ProtectsThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Distinct and Dynamic Changes in the Temporal Profiles of Neurotransmitters inPharmaceuticals (Basel, Switzerland) · 2023Article
- A network-based analysis detects cocaine-induced changes in social interactions in Drosophila melanogaster.PloS one · 2023Article
- Article
- Differential regulation of alcohol consumption and reward by the transcriptional cofactor LMO4.Molecular psychiatry · 2021Article
- Smoking flies: testing the effect of tobacco cigarettes on heart function ofBiology open · 2021Article
- EasyFlyTracker: A Simple Video Tracking Python Package for Analyzing AdultFrontiers in behavioral neuroscience · 2021Article
- Beadex, a homologue of the vertebrate LIM domain only protein, is a novel regulator of crystal cell development inJournal of genetics · 2019Article
- Genetics of cocaine and methamphetamine consumption and preference in Drosophila melanogaster.PLoS genetics · 2019Article
- A Fly's Eye View of Natural and Drug Reward.Frontiers in physiology · 2018Review
- Review
- Using In Vitro Electrophysiology to Screen Medications: Accumbal Plasticity as an Engram of Alcohol Dependence.International review of neurobiology · 2016Article
- A Selective Role for Lmo4 in Cue-Reward Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Neurogenomics: An opportunity to integrate neuroscience, genomics and bioinformatics research in Africa.Applied & translational genomics · 2015Review
- Targeting G protein coupled receptor-related pathways as emerging molecular therapies.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2015Review
- Article
- LIM-domain-only proteins: multifunctional nuclear transcription coregulators that interacts with diverse proteins.Molecular biology reports · 2014Review
- Cocaine affects foraging behaviour and biogenic amine modulated behavioural reflexes in honey bees.PeerJ · 2014Article
- EGFR and FGFR pathways have distinct roles in Drosophila mushroom body development and ethanol-induced behavior.PloS one · 2014Article
- Cocaine tolerance in honey bees.PloS one · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In the last decade, the fruit fly Drosophila melanogaster, highly accessible to genetic, behavioral and molecular analyses, has been introduced as a novel model organism to help decipher the complex genetic, neurochemical, and neuroanatomical underpinnings of behaviors induced by drugs of abuse. Here we review these data, focusing specifically on cocaine-related behaviors. Several of cocaine's most characteristic properties have been recapitulated in Drosophila. First, cocaine induces motor behaviors in flies that are remarkably similar to those observed in mammals. Second, repeated cocaine administration induces behavioral sensitization a form of behavioral plasticity believed to underlie certain aspects of addiction. Third, a key role for dopaminergic systems in mediating cocaine's effects has been demonstrated through both pharmacological and genetic methods. Finally, and most importantly, unbiased genetic screens, feasible because of the simplicity and scale with which flies can be manipulated in the laboratory, have identified several novel genes and pathways whose role in cocaine behaviors had not been anticipated. Many of these genes and pathways have been validated in mammalian models of drug addiction. We focus in this review on the role of LIM-only proteins in cocaine-induced behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.