ArticleDevelopmental cell2008
Hox and senseless antagonism functions as a molecular switch to regulate EGF secretion in the Drosophila PNS.
Article in Developmental cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42 citing papers in PubMed, 63 citations in OpenAlex.
- The influence of Polycomb and Trithorax group function on the sexually dimorphic abdomen pigmentation of Drosophila melanogaster.G3 (Bethesda, Md.) · 2026Article
- Micromanagement ofJournal of developmental biology · 2022Review
- Mechanisms Underlying Hox-Mediated Transcriptional Outcomes.Frontiers in cell and developmental biology · 2021Review
- Conserved Gsx2/Ind homeodomain monomer versus homodimer DNA binding defines regulatory outcomes in flies and mice.Genes & development · 2021Article
- Maintenance of Cell Fate by the Polycomb Group Gene Sex Combs Extra Enables a Partial Epithelial Mesenchymal Transition inG3 (Bethesda, Md.) · 2020Article
- Novel mRNAs 3' end-associatedRNA (New York, N.Y.) · 2019Article
- Changes throughout a Genetic Network Mask the Contribution of Hox Gene Evolution.Current biology : CB · 2019Article
- The cis-regulatory logic underlying abdominal Hox-mediated repression versus activation of regulatory elements in Drosophila.Developmental biology · 2019Article
- Degenerate Pax2 and Senseless binding motifs improve detection of low-affinity sites required for enhancer specificity.PLoS genetics · 2018Article
- A Hox complex activates and potentiates the Epidermal Growth Factor signaling pathway to specify Drosophila oenocytes.PLoS genetics · 2017Article
- Regulatory logic driving stable levels ofDevelopment (Cambridge, England) · 2017Article
- Mechanisms of Specificity for Hox Factor Activity.Journal of developmental biology · 2016Article
- To Be Specific or Not: The Critical Relationship Between Hox And TALE Proteins.Trends in genetics : TIG · 2016Review
- A Hox Transcription Factor Collective Binds a Highly Conserved Distal-less cis-Regulatory Module to Generate Robust Transcriptional Outcomes.PLoS genetics · 2016Article
- Inhibitory activities of short linear motifs underlie Hox interactome specificity in vivo.eLife · 2015Article
- The evolutionary origination and diversification of a dimorphic gene regulatory network through parallel innovations in cis and trans.PLoS genetics · 2015Article
- Rhomboid Enhancer Activity Defines a Subset of Drosophila Neural Precursors Required for Proper Feeding, Growth and Viability.PloS one · 2015Article
- The intersection of the extrinsic hedgehog and WNT/wingless signals with the intrinsic Hox code underpins branching pattern and tube shape diversity in the drosophila airways.PLoS genetics · 2015Article
- Genetic dissection of photoreceptor subtype specification by the Drosophila melanogaster zinc finger proteins elbow and no ocelli.PLoS genetics · 2014Article
- Homothorax and Extradenticle alter the transcription factor network in Drosophila ommatidia at the dorsal rim of the retina.Development (Cambridge, England) · 2014Article
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5 authors at 1 institution in 1 country.
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Abstract
Hox factors are key regulators of distinct cells, tissues, and organs along the body plan. However, little is known about how Hox factors regulate cell-specific gene expression to pattern diverse tissues. Here, we show an unexpected Hox transcriptional mechanism: the permissive regulation of EGF secretion, and thereby cell specification, by antagonizing the Senseless transcription factor in the peripheral nervous system. rhomboid expression in a subset of sensory cells stimulates EGF secretion to induce hepatocyte-like cell development. We identified a rhomboid enhancer that is active in these cells and show that an abdominal Hox complex directly competes with Senseless for enhancer binding, with the transcriptional outcome dependent upon their relative binding activities. Thus, Hox-Senseless antagonism forms a molecular switch that integrates neural and anterior-posterior positional information. As the vertebrate senseless homolog is essential for neural development as well as hematopoiesis, we propose Hox-Senseless antagonism will broadly control cell fate decisions.
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