ArticleBMC genetics2008
Genetic variation in a member of the laminin gene family affects variation in body composition in Drosophila and humans.
Article in BMC genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner.Genes & nutrition · 2015Article
- High frequency of rare variants with a moderate-to-high predicted biological effect in protocadherin genes of extremely obese.Genes & nutrition · 2014Article
- Laminin α4 deficient mice exhibit decreased capacity for adipose tissue expansion and weight gain.PloS one · 2014Article
- Nuclear genomic control of naturally occurring variation in mitochondrial function in Drosophila melanogaster.BMC genomics · 2012Article
- Common variants in the LAMA5 gene associate with fasting plasma glucose and serum triglyceride levels in a cohort of pre-and early pubertal children.Journal of pediatric genetics · 2012Article
- Association of a common LAMA5 variant with anthropometric and metabolic traits in an Italian cohort of healthy elderly subjects.Experimental gerontology · 2011Article
- A conserved role for syndecan family members in the regulation of whole-body energy metabolism.PloS one · 2010Article
- Obesity genes: so close and yet so far...Journal of biology · 2008Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe objective of the present study was to map candidate loci influencing naturally occurring variation in triacylglycerol (TAG) storage using quantitative complementation procedures in Drosophila melanogaster. Based on our results from Drosophila, we performed a human population-based association study to investigate the effect of natural variation in LAMA5 gene on body composition in humans.
resultsWe identified four candidate genes that contributed to differences in TAG storage between two strains of D. melanogaster, including Laminin A (LanA), which is a member of the alpha subfamily of laminin chains. We confirmed the effects of this gene using a viable LanA mutant and showed that female flies homozygous for the mutation had significantly lower TAG storage, body weight, and total protein content than control flies. Drosophila LanA is closely related to human LAMA5 gene, which maps to the well-replicated obesity-linkage region on chromosome 20q13.2-q13.3. We tested for association between three common single nucleotide polymorphisms (SNPs) in the human LAMA5 gene and variation in body composition and lipid profile traits in a cohort of unrelated women of European American (EA) and African American (AA) descent. In both ethnic groups, we found that SNP rs659822 was associated with weight (EA: P = 0.008; AA: P = 0.05) and lean mass (EA: P= 0.003; AA: P = 0.03). We also found this SNP to be associated with height (P = 0.01), total fat mass (P = 0.01), and HDL-cholesterol (P = 0.003) but only in EA women. Finally, significant associations of SNP rs944895 with serum TAG levels (P = 0.02) and HDL-cholesterol (P = 0.03) were observed in AA women.
conclusionOur results suggest an evolutionarily conserved role of a member of the laminin gene family in contributing to variation in weight and body composition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.