ArticleTraffic (Copenhagen, Denmark)2008
Arabidopsis has two functional orthologs of the yeast V-ATPase assembly factor Vma21p.
Article in Traffic (Copenhagen, Denmark), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- The Lack of a COPII Cargo Receptor Erv14 Impacts Physiological Functions of the Vacuole in Saccharomyces cerevisiae.Traffic (Copenhagen, Denmark) · 2026Article
- Recent advances in the clinical spectrum and pathomechanisms associated with X-linked myopathy with excessive autophagy and otherJournal of neuromuscular diseases · 2025Review
- Detection of Stress-Induced Changes in Subcellular Protein Distribution.Methods in molecular biology (Clifton, N.J.) · 2024Article
- The cytosolic N-terminal domain of V-ATPase a-subunits is a regulatory hub targeted by multiple signals.Frontiers in molecular biosciences · 2023Review
- The Plant V-ATPase.Frontiers in plant science · 2022Review
- Article
- Some assembly required: Contributions of Tom Stevens' lab to the V-ATPase field.Traffic (Copenhagen, Denmark) · 2018Review
- The endoplasmic reticulum is the main membrane source for biogenesis of the lytic vacuole in Arabidopsis.The Plant cell · 2013Article
- PDMP induces rapid changes in vacuole morphology in Arabidopsis root cells.Journal of experimental botany · 2013Article
- The membrane-tethered transcription factor ANAC089 serves as redox-dependent suppressor of stromal ascorbate peroxidase gene expression.Frontiers in plant science · 2012Article
- Regulation of membrane trafficking and organ separation by the NEVERSHED ARF-GAP protein.Development (Cambridge, England) · 2009Article
- Voa1p functions in V-ATPase assembly in the yeast endoplasmic reticulum.Molecular biology of the cell · 2008Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
How individual protein subunits assemble into the higher order structure of a protein complex is not well understood. Four proteins dedicated to the assembly of the V(0) subcomplex of the V-adenosine triphosphatase (V-ATPase) in the endoplasmic reticulum (ER) have been identified in yeast, but their precise mode of molecular action remains to be identified. In contrast to the highly conserved subunits of the V-ATPase, orthologs of the yeast assembly factors are not easily identified based on sequence similarity. We show in this study that two ER-localized Arabidopsis proteins that share only 25% sequence identity with Vma21p can functionally replace this yeast assembly factor. Loss of AtVMA21a function in RNA interference seedlings caused impaired cell expansion and changes in Golgi morphology characteristic for plants with reduced V-ATPase activity, and we therefore conclude that AtVMA21a is the first V-ATPase assembly factor identified in a multicellular eukaryote. Moreover, VMA21p acts as a dedicated ER escort chaperone, a class of substrate-specific accessory proteins so far not identified in higher plants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.