ArticlePsychoneuroendocrinology2008
Activation of 5-HT1A autoreceptors in the dorsal raphe nucleus reduces the behavioral consequences of social defeat.
Article in Psychoneuroendocrinology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 53 citations in OpenAlex.
- Serotonin modulates social responses to stressed conspecifics via insular 5-HTNeuropharmacology · 2023Article
- Cannabidiol and the corticoraphe circuit in post-traumatic stress disorder.IBRO neuroscience reports · 2021Review
- Article
- Reduced Consolation Behaviors in Physically Stressed Mandarin Voles: Involvement of Oxytocin, Dopamine D2, and Serotonin 1A Receptors Within the Anterior Cingulate Cortex.The international journal of neuropsychopharmacology · 2020Article
- Activity of a vmPFC-DRN Pathway Corresponds With Resistance to Acute Social Defeat Stress.Frontiers in neural circuits · 2020Article
- The effects of psychosocial stress on dopaminergic function and the acute stress response.eLife · 2019Article
- Serotonin Signaling Trough Prelimbic 5-HT1A Receptors Modulates CSDS-Induced Behavioral Changes in Adult Female Voles.The international journal of neuropsychopharmacology · 2019Article
- Cognitive Control as a 5-HTFrontiers in psychology · 2019Article
- Interaction of basolateral amygdala, ventral hippocampus and medial prefrontal cortex regulates the consolidation and extinction of social fear.Behavioral and brain functions : BBF · 2018Article
- Dominance status alters restraint-induced neural activity in brain regions controlling stress vulnerability.Physiology & behavior · 2017Article
- Sex Differences in the Regulation of Offensive Aggression and Dominance by Arginine-Vasopressin.Frontiers in endocrinology · 2017Review
- Treadmill exercise ameliorates intracerebral hemorrhage-induced depression in rats.Journal of exercise rehabilitation · 2016Article
- Neurobiological mechanisms supporting experience-dependent resistance to social stress.Neuroscience · 2015Review
- Nonexocytotic serotonin release tonically suppresses serotonergic neuron activity.The Journal of general physiology · 2015Article
- Activation of 5-HT2a receptors in the basolateral amygdala promotes defeat-induced anxiety and the acquisition of conditioned defeat in Syrian hamsters.Neuropharmacology · 2015Article
- Social status differences regulate the serotonergic system of a cichlid fish, Astatotilapia burtoni.The Journal of experimental biology · 2014Article
- 5-HT1A receptor activation reduces fear-related behavior following social defeat in Syrian hamsters.Pharmacology, biochemistry, and behavior · 2014Article
- Neural circuit interactions between the dorsal raphe nucleus and the lateral hypothalamus: an experimental and computational study.PloS one · 2014Article
- Defeat-induced activation of the ventral medial prefrontal cortex is necessary for resistance to conditioned defeat.Behavioural brain research · 2013Article
- Contrasting hippocampal and amygdalar expression of genes related to neural plasticity during escape from social aggression.Physiology & behavior · 2012Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
In animal models, serotonin (5-HT) activity contributes to stress-induced changes in behavior. Syrian hamsters (Mesocricetus auratus) exhibit a stress-induced change in behavior in which social defeat results in increased submissive and defensive behavior and a complete loss of normal territorial aggression directed toward a novel, non-aggressive opponent. We refer to this defeat-induced change in agonistic behavior as conditioned defeat. In this study we tested the hypothesis that 5-HT activity in the dorsal raphe nucleus (DRN) contributes to the acquisition and expression of conditioned defeat. We investigated whether injection of the selective 5-HT1A agonist flesinoxan (200 ng, 400 ng, or 800 ng in 200 nl saline) into the DRN would reduce the acquisition and expression of conditioned defeat. Additionally, we investigated whether injection of the selective 5-HT1A antagonist WAY 100635 (400 ng in 200 nl saline) into the DRN would enhance the acquisition and expression of conditioned defeat following a sub-optimal social defeat experience. We found that injection of flesinoxan into the DRN before exposure to a 15-min social defeat reduced the amount of submissive and defensive behavior shown at testing. We also found that injection of flesinoxan into the DRN before testing similarly reduced submissive and defensive behavior. In addition, we found that WAY 100635 enhanced conditioned defeat when injected either before social defeat or before testing. These data support the hypothesis that the activity of 5-HT cells in the DRN, as regulated by 5-HT1A autoreceptors, contributes to the formation and display of conditioned defeat. Further, our results suggest that 5-HT release in DRN projection regions augments defeat-induced changes in social behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.