ArticleFertility and sterility2009
Morbid obesity is associated with lower clinical pregnancy rates after in vitro fertilization in women with polycystic ovary syndrome.
Article in Fertility and sterility, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03034941 (Short Term Weight Loss With Liraglutide and Metformin Before IVF in Infertile Obese PCOS Patients), which is not on this map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Short Term Weight Loss With Liraglutide and Metformin Before IVF in Infertile Obese PCOS Patients
Open the trial in the graphWho cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 124 citations in OpenAlex.
- IVF outcomes in obese donor oocyte recipients: a systematic review and meta-analysis.Human reproduction (Oxford, England) · 2013Pooled it
- The Lifestyle Modifications and Endometrial Proteome Changes of Women With Polycystic Ovary Syndrome and Obesity.Frontiers in endocrinology · 2022Trial
- Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization.Fertility and sterility · 2011Trial
- Alnustone ameliorates obesity and polycystic ovary syndrome by remodeling adipose metabolism via AMPK signaling.Science China. Life sciences · 2026Article
- Outcomes of ovulation induction in obese women with infertility after bariatric surgery.F&S reports · 2025Article
- The Effect of BMI and Lipid Metabolism on Pregnancy Outcomes of PCOS Patients Treated with ICSI_IVF.Journal of obstetrics and gynaecology of India · 2024Article
- Overweight and obesity determined by body mass index criteria for Asian populations adversely affect assisted reproductive outcomes among Chinese women with polycystic ovary syndrome.International journal of obesity (2005) · 2024Article
- Adiposity and lipid metabolism indicators mediate the adverse effect of glucose metabolism indicators on oogenesis and embryogenesis in PCOS women undergoing IVF/ICSI cycles.European journal of medical research · 2023Article
- Article
- Female infertility in the era of obesity: The clash of two pandemics or inevitable consequence?Clinical endocrinology · 2023Review
- Review
- Effects of hypercaloric diet-induced hyperinsulinemia and hyperlipidemia on the ovarian follicular development in mice.The Journal of reproduction and development · 2022Article
- Impact of body mass index (BMI) on the success rate of fresh embryo transfer in women undergoing first in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment.International journal of obesity (2005) · 2022Article
- Gene cascade analysis in human granulosa tumor cells (KGN) following exposure to high levels of free fatty acids and insulin.Journal of ovarian research · 2021Article
- The Impact of COVID-19 Lockdown on Weight Loss Program in Infertile Polycystic Ovary Syndrome Women with Obesity.Obesity facts · 2021Article
- Fundamental Concepts and Novel Aspects of Polycystic Ovarian Syndrome: Expert Consensus Resolutions.Frontiers in endocrinology · 2020Review
- Proteomic profile of follicular fluid from patients with polycystic ovary syndrome (PCOS) submitted to in vitro fertilization (IVF) compared to oocyte donors.JBRA assisted reproduction · 2019Article
- The Effects of Overweight and Obesity on Assisted Reproduction Technology Outcomes.JBRA assisted reproduction · 2019Article
- Female infertility: which role for obesity?International journal of obesity supplements · 2019Review
- The effect of female body mass index on in vitro fertilization cycle outcomes: a multi-center analysis.Journal of assisted reproduction and genetics · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine whether morbid obesity is associated with decreased pregnancy and live birth rates after IVF in women with polycystic ovary syndrome (PCOS).
designRetrospective cohort study.
settingUniversity-based fertility center. PATIENT(S): Seventy-two women with PCOS who completed their first IVF cycle between 2001 and 2006. INTERVENTION(S): Outcomes of IVF were compared between women with a body mass index (BMI) of <40 kg/m(2) vs. those with a BMI of > or =40 kg/m(2). MAIN OUTCOME MEASURE(S): Clinical pregnancy rate, live birth rate. RESULT(S): Morbidly obese women with PCOS (n = 19) had significantly lower clinical pregnancy rates after IVF than patients with PCOS who were not morbidly obese (n = 53) (32% vs. 72%, relative risk 0.44, 95% confidence interval 0.22-0.87). Their live birth rates were lower too, although this difference was not statistically significant (32% vs. 60%, relative risk 0.52, 95% confidence interval 0.26-1.05). CONCLUSION(S): Morbid obesity is associated with lower pregnancy rates in women with PCOS after IVF, raising the question of whether weight loss may improve IVF success rates for morbidly obese PCOS patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.