Trial reportFertility and sterility2009
Enhanced neuroactivation during verbal memory processing in postmenopausal women receiving short-term hormone therapy.
Trial report in Fertility and sterility, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Distinct cognitive effects of estrogen and progesterone in menopausal women.Psychoneuroendocrinology · 2015Trial
- Differences in regional brain metabolism associated with specific formulations of hormone therapy in postmenopausal women at risk for AD.Psychoneuroendocrinology · 2011Trial
- Perimenopausal use of hormone therapy is associated with enhanced memory and hippocampal function later in life.Brain research · 2011Trial
- Short-term hormone treatment modulates emotion response circuitry in postmenopausal women.Fertility and sterility · 2010Trial
- Effects of Hormone Therapy on List and Story Recall in Post-Menopausal Women.Experimental aging researchTrial
- Associations Between Midlife Menopausal Hormone Therapy Use, Incident Diabetes, and Late Life Memory in the Wisconsin Longitudinal Study.Journal of Alzheimer's disease : JAD · 2023Article
- 17β-estradiol ameliorates delirium-like phenotypes in a murine model of urinary tract infection.Scientific reports · 2022Article
- Ovarian steroid hormones: A long overlooked but critical contributor to brain aging and Alzheimer's disease.Frontiers in aging neuroscience · 2022Review
- G Protein-Coupled Estrogen Receptor 1 Knockout Deteriorates MK-801-Induced Learning and Memory Impairment in Mice.Frontiers in behavioral neuroscience · 2020Article
- Impact of sex steroids and reproductive stage on sleep-dependent memory consolidation in women.Neurobiology of learning and memory · 2019Review
- Inflammation: Bridging Age, Menopause and APOEε4 Genotype to Alzheimer's Disease.Frontiers in aging neuroscience · 2018Review
- Sex and post-menopause hormone therapy effects on hippocampal volume and verbal memory.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2017Article
- A comparison of progestins within three classes: Differential effects on learning and memory in the aging surgically menopausal rat.Behavioural brain research · 2017Article
- Enhanced Neuroactivation during Working Memory Task in Postmenopausal Women Receiving Hormone Therapy: A Coordinate-Based Meta-Analysis.Frontiers in human neuroscience · 2015Review
- Functional and molecular neuroimaging of menopause and hormone replacement therapy.Frontiers in neuroscience · 2014Review
- Alzheimer disease in post-menopausal women: Intervene in the critical window period.Journal of mid-life health · 2014Article
- Alterations in brain activation during working memory processing associated with breast cancer and treatment: a prospective functional magnetic resonance imaging study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2012Article
- Interactive effects of estrogen and serotonin on brain activation during working memory and affective processing in menopausal women.Psychoneuroendocrinology · 2012Article
- Hormone replacement therapy and risk for neurodegenerative diseases.International journal of Alzheimer's disease · 2012Article
- Covariance modeling of MRI brain volumes in memory circuitry in schizophrenia: Sex differences are critical.NeuroImage · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo study the effects of hormone therapy on brain activation patterns during verbal memory in postmenopausal women.
designA randomized, double-blind placebo-controlled cross-over study was performed.
settingA tertiary care university medical center. PATIENT(S): Ten healthy postmenopausal women (age range 56-60 years) were recruited from the local community. INTERVENTION(S): Women were randomized to the order they received combined hormone therapy, 5 microg of ethinyl E(2) and 1 mg of norethindrone acetate, and placebo. Volunteers received hormone therapy or placebo for 4 weeks, followed by a 1-month washout period, and then received the other treatment for 4 weeks. A functional magnetic resonance imaging (fMRI) was performed at the end of each 4-week treatment using a verbal memory task. MAIN OUTCOME MEASURE(S): Brain activation patterns were compared between hormone therapy and placebo. RESULT(S): Hormone therapy was associated with increased activation in the left middle/superior frontal cortex (BA 6,9), medial frontal cortex and dorsal anterior cingulate (BA 24,32), posterior cingulate (BA 6), and left inferior parietal cortex (BA 40) during memory encoding. All regions were significant with correction for multiple comparisons. CONCLUSION(S): Hormone therapy increased neural activation in frontal and parietal areas in postmenopausal women during a verbal memory task.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.