ArticleMolecular and cellular neurosciences2008
Assessment of functional recovery and axonal sprouting in oligodendrocyte-myelin glycoprotein (OMgp) null mice after spinal cord injury.
Article in Molecular and cellular neurosciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 62 citations in OpenAlex.
- Systemic delivery of drug-free polymeric nanoparticles reprograms innate immunity in a sex-dependent manner after spinal cord injury.bioRxiv : the preprint server for biology · 2026Article
- Targeting Remyelination in Spinal Cord Injury: Insights and Emerging Therapeutic Strategies.CNS neuroscience & therapeutics · 2024Review
- Axonal growth inhibitors and their receptors in spinal cord injury: from biology to clinical translation.Neural regeneration research · 2023Review
- Development of Neurogenic Detrusor Overactivity after Thoracic Spinal Cord Injury Is Accompanied by Time-Dependent Changes in Lumbosacral Expression of Axonal Growth Regulators.International journal of molecular sciences · 2022Article
- One Raft to Guide Them All, and in Axon Regeneration Inhibit Them.International journal of molecular sciences · 2021Review
- Oligodendrocytic but not neuronal Nogo restricts corticospinal axon sprouting after CNS injury.Experimental neurology · 2018Article
- Local Immunomodulation with Anti-inflammatory Cytokine-Encoding Lentivirus Enhances Functional Recovery after Spinal Cord Injury.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- Rewiring the spinal cord: Direct and indirect strategies.Neuroscience letters · 2017Review
- The Ubiquitin-Proteasome System: Potential Therapeutic Targets for Alzheimer's Disease and Spinal Cord Injury.Frontiers in molecular neuroscience · 2016Review
- Ameliorative Effects of p75NTR-ED-Fc on Axonal Regeneration and Functional Recovery in Spinal Cord-Injured Rats.Molecular neurobiology · 2015Article
- Effects of PTEN and Nogo Codeletion on Corticospinal Axon Sprouting and Regeneration in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- MAG, myelin and overcoming growth inhibition in the CNS.Frontiers in molecular neuroscience · 2015Review
- Myelin-associated inhibitors in axonal growth after CNS injury.Current opinion in neurobiology · 2014Review
- Axon growth inhibition by RhoA/ROCK in the central nervous system.Frontiers in neuroscience · 2014Review
- Expression and cellular distribution of ubiquitin in response to injury in the developing spinal cord of Monodelphis domestica.PloS one · 2013Article
- Neural regeneration: lessons from regenerating and non-regenerating systems.Molecular neurobiology · 2012Review
- Role of myelin-associated inhibitors in axonal repair after spinal cord injury.Experimental neurology · 2012Review
- Myelin associated inhibitors: a link between injury-induced and experience-dependent plasticity.Experimental neurology · 2012Review
- Hippocampal expression of myelin-associated inhibitors is induced with age-related cognitive decline and correlates with deficits of spatial learning and memory.Journal of neurochemistry · 2012Article
- Receptor tyrosine kinases: molecular switches regulating CNS axon regeneration.Journal of signal transduction · 2012Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
Oligodendrocyte-myelin glycoprotein (OMgp) is a myelin component that has been shown in vitro to inhibit neurite outgrowth by binding to the Nogo-66 receptor (NgR1)/Lingo-1/Taj (TROY)/p75 receptor complex to activate the RhoA pathway. To investigate the effects of OMgp on axon regeneration in vivo, OMgp(-/-) mice on a mixed 129/Sv/C57BL/6 (129BL6) or a C57BL/6 (BL6) genetic background were tested in two spinal cord injury (SCI) models - a severe complete transection or a milder dorsal hemisection. OMgp(-/-) mice on the mixed 129BL6 genetic background showed greater functional improvement compared to OMgp(+/+) littermates, with increased numbers of cholera toxin B-labeled ascending sensory axons and 5-HT(+) descending axons and less RhoA activation after spinal cord injury. Myelin isolated from OMgp(-/-) mice (129BL6) was significantly less inhibitory to neurite outgrowth than wild-type (wt) myelin in vitro. However, OMgp(-/-) mice on a BL/6 genetic background showed neither statistically significant functional recovery nor axonal sprouting following dorsal hemisection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.