ArticleJournal of autoimmunity2008
Co-occurrence of celiac disease and other autoimmune diseases in celiacs and their first-degree relatives.
Article in Journal of autoimmunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 132 citations in OpenAlex.
- Prevalence of celiac disease in latin america: a systematic review and meta-regression.PloS one · 2015Pooled it
- How do autoimmune diseases cluster in families? A systematic review and meta-analysis.BMC medicine · 2013Pooled it
- Celiac disease increases the risk of pulmonary arterial hypertension: A multivariable Mendelian randomization and mediation analysis.Medicine · 2026Article
- Autoimmune disease in offspring of mothers with metabolic dysfunction-associated steatotic liver disease (MASLD): a nationwide cohort study.Scientific reports · 2026Article
- Association of Individual or Family History of Autoimmune Disease With Future Development of Type 1 Diabetes.Diabetes/metabolism research and reviews · 2026Review
- Liver Involvement in Celiac Disease and Immune-Mediated Diseases of the Small Bowel.Liver international : official journal of the International Association for the Study of the Liver · 2025Review
- Celiac Disease and Autoimmune Diseases in a Pediatric Population in Morocco: A Cross-Sectional Study.Cureus · 2024Article
- Beyond the Gut: A Systematic Review of Oral Manifestations in Celiac Disease.Journal of clinical medicine · 2023Review
- Coeliac Disease Case-Control Study: Has the Time Come to Explore beyond Patients at Risk?Nutrients · 2023Article
- Is There a Predictive Factor for an Association with Autoimmune Glandular Disease in Children Diagnosed with Celiac Disease?Journal of clinical research in pediatric endocrinology · 2022Article
- The Impact of Cereal Grain Composition on the Health and Disease Outcomes.Frontiers in nutrition · 2022Review
- Thromboembolic complications and cardiovascular events associated with celiac disease.Irish journal of medical science · 2021Review
- Prevalence of coexisting autoimmune thyroidal diseases in coeliac disease is decreasing.United European gastroenterology journal · 2020Article
- Celiac Disease: Against the Grain in Gastroenterology.Journal of the Canadian Association of Gastroenterology · 2019Article
- Prevalence of thyroid autoimmunity in first-degree relatives of patients with celiac disease.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2019Article
- Overlap of Characteristic Serological Antibodies in Rheumatoid Arthritis and Wheat-Related Disorders.Disease markers · 2019Article
- Gluten Immunogenic Peptides as Standard for the Evaluation of Potential Harmful Prolamin Content in Food and Human Specimen.Nutrients · 2018Review
- Celiac Disease-Musculoskeletal Manifestations and Mechanisms in Children to Adults.Current osteoporosis reports · 2018Review
- Risk Factors Associated with the Occurrence of Autoimmune Diseases in Adult Coeliac Patients.Gastroenterology research and practice · 2018Article
- Exceptional manifestation of polyautoimmunity in a very young girl - a case report.Central-European journal of immunology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
The occurrence of other autoimmune diseases in celiac disease families has not been previously reported in a North American population. We investigated the familial aggregation of rheumatoid arthritis (RA), juvenile rheumatoid arthritis/juvenile idiopathic arthritis (JRA/JIA), hypothyroidism, insulin dependent diabetes mellitus (IDDM), and alopecia areata (AA) among individuals in families with celiac disease (CD). Family history information, obtained from questionnaires from the University of California Irvine Celiac Disease study, was reviewed for reports of RA, JRA/JIA, hypothyroidism, IDDM, and AA in celiac disease cases and their first-degree relatives. Reports of disease were compared with prevalence data from the literature and analyzed by calculating the standardized ratio (SR) with 95% confidence limits. We analyzed: (1) subjects with confirmed celiac disease or dermatitis herpetiformis (205 probands and 203 affected first-degree relatives) and (2) first-degree relatives of celiac disease cases (n=1272). We found a significantly increased number of cases, relative to the expected number, of IDDM in both groups and hypothyroidism among subjects with celiac disease. JRA/JIA was increased among first-degree relatives of celiacs. These results indicate that the presence of IDDM within our celiac disease families may be due to shared genetic susceptibility predisposing to these diseases or autoimmune diseases in general.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.