ArticleDevelopmental biology2008
GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors.
Article in Developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 42 citations in OpenAlex.
- Low expression of CCKBR in the acinar cells is associated with insufficient starch hydrolysis in ruminants.Communications biology · 2024Article
- GATA4/5/6 family transcription factors are conserved determinants of cardiac versus pharyngeal mesoderm fate.Science advances · 2022Article
- Identification of Biomarkers Controlling Cell Fate In Blood Cell Development.Frontiers in bioinformatics · 2021Article
- Inactivation of the GATA Cofactor ZFPM1 Results in Abnormal Development of Dorsal Raphe Serotonergic Neuron Subtypes and Increased Anxiety-Like Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Patterning the gastrointestinal epithelium to confer regional-specific functions.Developmental biology · 2018Review
- Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling.Cell stem cell · 2017Article
- Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing.Nature medicine · 2017Article
- GATA4 Is Sufficient to Establish Jejunal Versus Ileal Identity in the Small Intestine.Cellular and molecular gastroenterology and hepatology · 2017Article
- Gata4 is critical to maintain gut barrier function and mucosal integrity following epithelial injury.Scientific reports · 2016Article
- Gut microbiota inhibit Asbt-dependent intestinal bile acid reabsorption via Gata4.Journal of hepatology · 2015Article
- MyoR modulates cardiac conduction by repressing Gata4.Molecular and cellular biology · 2015Article
- GATA4 represses an ileal program of gene expression in the proximal small intestine by inhibiting the acetylation of histone H3, lysine 27.Biochimica et biophysica acta · 2014Article
- The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression.Nature cell biology · 2014Article
- Role of GATA factors in development, differentiation, and homeostasis of the small intestinal epithelium.American journal of physiology. Gastrointestinal and liver physiology · 2014Review
- Spdef deletion rescues the crypt cell proliferation defect in conditional Gata6 null mouse small intestine.BMC molecular biology · 2014Article
- Function of GATA factors in the adult mouse liver.PloS one · 2013Article
- Intestinal mucosal atrophy and adaptation.World journal of gastroenterology · 2012Review
- Combinatorial regulation of tissue specification by GATA and FOG factors.Development (Cambridge, England) · 2012Review
- GATA6 is required for proliferation, migration, secretory cell maturation, and gene expression in the mature mouse colon.Molecular and cellular biology · 2012Article
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
GATA4, a transcription factor expressed in the proximal small intestine but not in the distal ileum, maintains proximal-distal distinctions by multiple processes involving gene repression, gene activation, and cell fate determination. Friend of GATA (FOG) is an evolutionarily conserved family of cofactors whose members physically associate with GATA factors and mediate GATA-regulated repression in multiple tissues. Using a novel, inducible, intestine-specific Gata4 knock-in model in mice, in which wild-type GATA4 is specifically inactivated in the small intestine, but a GATA4 mutant that does not bind FOG cofactors (GATA4ki) continues to be expressed, we found that ileal-specific genes were significantly induced in the proximal small intestine (P<0.01); in contrast, genes restricted to proximal small intestine and cell lineage markers were unaffected, indicating that GATA4-FOG interactions contribute specifically to the repression function of GATA4 within this organ. Fog1 mRNA displayed a proximal-distal pattern that parallels that of Gata4, and FOG1 protein was co-expressed with GATA4 in intestinal epithelial cells, implicating FOG1 as the likely mediator of GATA4 function in the small intestine. Our data are the first to indicate FOG function and expression in the mammalian small intestine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.