Evidence map›Paper›PMID 18691961›Full record

ArticleMolecular cell2008

Epigenetics? Mediator does that too!

Sohail Malik, Robert G Roeder

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Molecular cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 38 citations in OpenAlex.

  1. Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification ofClinical cancer research : an official journal of the American Association for Cancer Research · 2017
    Article
  2. Yin and yang of mediator function revealed by human mutants.Proceedings of the National Academy of Sciences of the United States of America · 2012
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sohail MalikLaboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. maliks@rockefeller.edu
Robert G Roeder
Rockefeller University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adding to the concept that Mediator acts as an "integrative hub,"Ding et al. (2008) report in this issue of Molecular Cell that, by facilitating the recruitment of the G9a methyl transferase, Mediator can also promote epigenetic silencing of selected genes.

Indexed as

Epigenesis, GeneticHeLa CellsHistocompatibility AntigensHistone-Lysine N-MethyltransferaseHumansMediator ComplexNeuronsRE1-Silencing Transcription FactorReceptors, Thyroid HormoneRepressor ProteinsSilencer Elements, TranscriptionalX-Linked Intellectual DisabilityEHMT2 protein, humanHistocompatibility AntigensHistone-Lysine N-MethyltransferaseMED12 protein, humanMediator ComplexRE1-Silencing Transcription FactorReceptors, Thyroid HormoneRepressor Proteins

Identifiers

PMID18691961
OpenAlexW2043340815

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.