ArticleCurrent biology : CB2008
Costal2 functions as a kinesin-like protein in the hedgehog signal transduction pathway.
Article in Current biology : CB, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- Cystatin antibodies interfere with ovary development in Haemaphysalis doenitzi (Acari: Ixodidae).PLoS neglected tropical diseases · 2025Article
- Gotta Go Slow: Two Evolutionarily Distinct Annelids Retain a Common Hedgehog Pathway Composition, Outlining Its Pan-Bilaterian Core.International journal of molecular sciences · 2022Article
- Article
- Signaling in the primary cilium through the lens of the Hedgehog pathway.Wiley interdisciplinary reviews. Developmental biology · 2020Review
- Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7.The Journal of cell biology · 2018Article
- Biophysical characterisation of the novel zinc binding property in Suppressor of Fused.Scientific reports · 2017Article
- Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination.PLoS genetics · 2016Article
- The small GTPase Rap1 is a modulator of Hedgehog signaling.Developmental biology · 2016Article
- The contrasting roles of primary cilia and cytonemes in Hh signaling.Developmental biology · 2014Article
- Computational modeling reveals optimal strategy for kinase transport by microtubules to nerve terminals.PloS one · 2014Article
- The mechanisms of Hedgehog signalling and its roles in development and disease.Nature reviews. Molecular cell biology · 2013Review
- Genetic interaction screens identify a role for hedgehog signaling in Drosophila border cell migration.Developmental dynamics : an official publication of the American Association of Anatomists · 2013Article
- Non-cell autonomous control of apoptosis by ligand-independent Hedgehog signaling in Drosophila.Cell death and differentiation · 2013Article
- The Hedgehog signal transduction network.Science signaling · 2012Review
- Ligand-independent activation of the Hedgehog pathway displays non-cell autonomous proliferation during eye development in Drosophila.Mechanisms of development · 2012Article
- Unconventional functions of microtubule motors.Archives of biochemistry and biophysics · 2012Review
- Kinesin motors and primary cilia.Biochemical Society transactions · 2011Review
- Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus.Cell research · 2011Article
- Mechanisms and functions of Hedgehog signalling across the metazoa.Nature reviews. Genetics · 2011Review
- Costal 2 interactions with Cubitus interruptus (Ci) underlying Hedgehog-regulated Ci processing.Developmental biology · 2010Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The Hedgehog (Hh) signaling pathway initiates an evolutionarily conserved developmental program required for the proper patterning of many tissues [1]. Although Costal2 (Cos2) is a requisite component of the Hh pathway, its mechanistic role is not well understood. Because of its primary sequence, Cos2 was initially predicted to function as a kinesin-like protein [2]. However, evidence showing that Cos2 function might require kinesin-like properties has been lacking [2-6]. Thus, the prevailing dogma in the field is that Cos2 functions solely as a scaffolding protein [7, 8]. Here, we show that Cos2 motility is required for its biological function and that this motility may be Hh regulated. We show that Cos2 motility requires an active motor domain, ATP, and microtubules. Additionally, Cos2 recruits and transports other components of the Hh signaling pathway, including the transcription factor Cubitus interruptus (Ci). Drosophila expressing cos2 mutations that encode proteins that lack motility are attenuated in their ability to regulate Ci activity and exhibit phenotypes consistent with attenuated Cos2 function [9]. Combined, these results demonstrate that Cos2 motility plays an important role in its function, regulating the amounts and activity of Ci that ultimately interpret the level of Hh to which cells are exposed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.