ReviewCurrent opinion in pharmacology2008
Sensing the microenvironment of the central nervous system: immune cells in the central nervous system and their pharmacological manipulation.
Review in Current opinion in pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Dysregulation of inflammasome activation in glioma.Cell communication and signaling : CCS · 2023Review
- Mapping lesion-specific response and progression dynamics and inter-organ variability in metastatic colorectal cancer.Nature communications · 2023Article
- An integrated cytokine and kynurenine network as the basis of neuroimmune communication.Frontiers in neuroscience · 2022Review
- Immunomodulatory effects of extracellular vesicles in glioblastoma.Frontiers in cell and developmental biology · 2022Review
- Multiomics profiling of primary lung cancers and distant metastases reveals immunosuppression as a common characteristic of tumor cells with metastatic plasticity.Genome biology · 2020Article
- Neuronal extracellular microRNAs miR-124 and miR-9 mediate cell-cell communication between neurons and microglia.Journal of neuroscience research · 2019Article
- Cross-talk between T Cells and Hematopoietic Stem Cells during Adoptive Cellular Therapy for Malignant Glioma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2018Article
- Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery.The Journal of physiology · 2018Article
- Dendritic cells as therapeutic targets in neuroinflammation.Cellular and molecular life sciences : CMLS · 2016Review
- Gene Therapy for the Treatment of Neurological Disorders: Central Nervous System Neoplasms.Methods in molecular biology (Clifton, N.J.) · 2016Article
- Immune privilege of the CNS is not the consequence of limited antigen sampling.Scientific reports · 2014Article
- Article
- Gene therapy for brain tumors: basic developments and clinical implementation.Neuroscience letters · 2012Review
- Modulation of tumor tolerance in primary central nervous system malignancies.Clinical & developmental immunology · 2012Review
- Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation.Journal of neuroinflammation · 2011Article
- Modulation of dendritic cell function by PGE2 and DHA: a framework for understanding the role of dendritic cells in neuroinflammation.Clinical lipidology · 2011Article
- Specialized pro-resolving lipid mediators in the inflammatory response: An update.Biochimica et biophysica acta · 2010Review
- The role of dendritic cells in CNS autoimmunity.Journal of molecular medicine (Berlin, Germany) · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Immune responses are highly regulated in all organs and severely restricted in certain tissues within the central nervous system (CNS). This phenomenon, called 'immune privilege', has been linked to the existence of multiple anatomical and physiological protective mechanisms. The finely balanced anti-inflammatory microenvironment within the CNS contributes to the immune privilege status of this tissue. The regulation of this compartment changes under pathological conditions when pro-inflammatory mediators might dominate. The past few years brought a wealth of novel information fostering our understanding of how CNS resident cells regulate the functions of immune cells, particularly helper T lymphocytes (Ths) and dendritic cells (DCs). These two cell types play a crucial role in the initiation and maintenance of neuroinflammatory diseases. The change from anti-inflammatory to pro-inflammatory microenvironment in the inflamed CNS affects Th and DC accumulation and function in the nervous tissue. A new era of DC-targeted therapies has begun, with the possibility of designing novel immunomodulatory therapies to intervene with neuroinflammation in a wide range of neurological diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.