ArticleNeuroImage2008
Tensor-based morphometry as a neuroimaging biomarker for Alzheimer's disease: an MRI study of 676 AD, MCI, and normal subjects.
Article in NeuroImage, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 211 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
211 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neural correlates of Alzheimer's disease and mild cognitive impairment: a systematic and quantitative meta-analysis involving 1351 patients.NeuroImage · 2009Pooled it
- Micro- and Macrostructural White Matter Integrity in Never-Treated and Currently Unmedicated Patients With Schizophrenia and Effects of Short-Term Antipsychotic Treatment.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Trial
- Regional gray matter atrophy in relapsing remitting multiple sclerosis: baseline analysis of multi-center data.Multiple sclerosis and related disorders · 2015Trial
- Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Boosting power for clinical trials using classifiers based on multiple biomarkers.Neurobiology of aging · 2010Trial
- Global and Medial Temporal MRI Morphometry in Alzheimer's Disease and Cognitively Normal Adults: A Retrospective Association Study.Diagnostics (Basel, Switzerland) · 2026Article
- Brain parenchyma deformation and strain in patients with spontaneous intracranial hypotension.Fluids and barriers of the CNS · 2026Article
- Understanding Trade-Offs in Continuous Neural Representations for Diffeomorphic Image Registration: A Comparative Study of Implicit Neural Representations and Neural Ordinary Differential Equations.Journal of imaging · 2026Article
- Postmortem neuropathologies are associated with retrospective tensor-based morphometry findings in Alzheimer's dementia continuum.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Deep-Diffeomorphic Networks for Conditional Brain Templates.Human brain mapping · 2025Article
- Decomposing the effect of normal aging and Alzheimer's disease in brain morphological changes via learned aging templates.Scientific reports · 2025Article
- Comparison of Explainable AI Models for MRI-based Alzheimer's Disease Classification.bioRxiv : the preprint server for biology · 2024Article
- Growth-Associated Protein 43 and Tensor-Based Morphometry Indices in Mild Cognitive Impairment.Neuroinformatics · 2024Article
- Brain Healthcare Quotient as a Tool for Standardized Approach in Brain Healthcare Interventions.Life (Basel, Switzerland) · 2024Article
- Normal-Tension Glaucoma and Potential Clinical Links to Alzheimer's Disease.Journal of clinical medicine · 2024Review
- The effects of a six-month exercise intervention on white matter microstructure in older adults at risk for diabetes.Cerebral circulation - cognition and behavior · 2024Article
- Regional deep atrophy: Using temporal information to automatically identify regions associated with Alzheimer's disease progression from longitudinal MRI.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Enabling uncertainty estimation in neural networks through weight perturbation for improved Alzheimer's disease classification.Frontiers in neuroinformatics · 2024Article
- Longitudinal Relationship Between Brain Atrophy Patterns, Cognitive Decline, and Cerebrospinal Fluid Biomarkers in Alzheimer's Disease Explored by Orthonormal Projective Non-Negative Matrix Factorization.Journal of Alzheimer's disease : JAD · 2024Article
- Explainability of random survival forests in predicting conversion risk from mild cognitive impairment to Alzheimer's disease.Brain informatics · 2023Article
151 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
In one of the largest brain MRI studies to date, we used tensor-based morphometry (TBM) to create 3D maps of structural atrophy in 676 subjects with Alzheimer's disease (AD), mild cognitive impairment (MCI), and healthy elderly controls, scanned as part of the Alzheimer's Disease Neuroimaging Initiative (ADNI). Using inverse-consistent 3D non-linear elastic image registration, we warped 676 individual brain MRI volumes to a population mean geometric template. Jacobian determinant maps were created, revealing the 3D profile of local volumetric expansion and compression. We compared the anatomical distribution of atrophy in 165 AD patients (age: 75.6+/-7.6 years), 330 MCI subjects (74.8+/-7.5), and 181 controls (75.9+/-5.1). Brain atrophy in selected regions-of-interest was correlated with clinical measurements--the sum-of-boxes clinical dementia rating (CDR-SB), mini-mental state examination (MMSE), and the logical memory test scores - at voxel level followed by correction for multiple comparisons. Baseline temporal lobe atrophy correlated with current cognitive performance, future cognitive decline, and conversion from MCI to AD over the following year; it predicted future decline even in healthy subjects. Over half of the AD and MCI subjects carried the ApoE4 (apolipoprotein E4) gene, which increases risk for AD; they showed greater hippocampal and temporal lobe deficits than non-carriers. ApoE2 gene carriers--1/6 of the normal group--showed reduced ventricular expansion, suggesting a protective effect. As an automated image analysis technique, TBM reveals 3D correlations between neuroimaging markers, genes, and future clinical changes, and is highly efficient for large-scale MRI studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.