ArticleInternal and emergency medicine2009
Eligibility criteria in heart failure randomized controlled trials: a gap between evidence and clinical practice.
Article in Internal and emergency medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Integrating Findings Into Practice: Assessing External Validity of Congestive Heart Failure Trials.Cardiology research · 2026Article
- A novel approach to assessing disparity in representativeness of clinical trial participants within a large midwestern healthcare system.Contemporary clinical trials communications · 2024Article
- Eligible-and-enrolled vs. eligible-but-not-enrolled patients with chronic ischaemic heart failure in randomized clinical trials of myocardial regeneration.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2022Article
- Prognostic association of medication trajectories with 3-year mortality in heart failure and preserved ejection fraction: findings from the EPICAL2 cohort study.European journal of clinical pharmacology · 2021Observational
- Clinical comparison between trial participants and potentially eligible patients using electronic health record data: A generalizability assessment method.Journal of biomedical informatics · 2021Article
- Translating evidence into practice: eligibility criteria fail to eliminate clinically significant differences between real-world and study populations.NPJ digital medicine · 2020Article
- Strategies to address the shortcomings of commonly used advanced chronic heart failure descriptors to improve recruitment in palliative care research: A parallel mixed-methods feasibility study.Palliative medicine · 2018Article
- Guidelines on the management of atrial fibrillation in the emergency department: a critical appraisal.Internal and emergency medicine · 2017Article
- Article
- Italian guidelines on thrombolysis indications in ischemic stroke have been revised after IST-3 trial and Cochrane revision: cons.Internal and emergency medicine · 2013Article
- Managing older patients with coexistent asthma and chronic obstructive pulmonary disease: diagnostic and therapeutic challenges.Drugs & aging · 2013Review
- Eplerenone, an aldosterone antagonist, reduces hospitalization and death in heart failure patients with NYHA class II and an ejection fraction of less than 30%.Internal and emergency medicine · 2011Article
- In-hospital management of heart failure: in 10 years we have improved, but not enough.Internal and emergency medicine · 2011Article
- Ivabradine added to guidelines-based therapy in systolic heart failure patients.Internal and emergency medicine · 2011Article
- Understanding results of trials in heart failure with preserved ejection fraction: remembering forgotten lessons and enduring principles.Journal of the American College of Cardiology · 2011Article
- Clinical trials in heart failure: may we trust?Internal and emergency medicine · 2009Article
- Evidence based medicine or interpretation of evidence based medicine?Internal and emergency medicine · 2009Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to compare the characteristics of patients referred to our heart failure outpatient clinic with those of patients enrolled in clinical trials on heart failure pharmacological treatment. Thus, we estimated the proportion of patients admitted to our heart failure outpatient clinic who would have been included in randomized controlled trials evaluating the effects of medical treatments on heart failure mortality, published over a 10 years period (1993-2003). Sixteen studies (n = 45276) and 299 consecutive outpatients, were included. On average, only 34% of the outpatients would have been included in at least one of the 16 trials (8-71%). The main reasons for exclusion were: NYHA class (70% were in NYHA class II), ejection fraction (29% had EF > 35%), co-morbidity (51% had co-morbidity, mainly renal failure, COPD, and disthyroidism), age (22% were older than 80 years), and occurrence of a recent acute event (50% experienced an ischemic coronary syndrome, revascularization, pulmonary edema, or stroke in the prior 6 months). These results underline the crucial role of patient selection in clinical trials, raising uncertainties about the complete applicability of trial results to clinical practice.
Indexed as
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18690492What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.