ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2009
Local chemotherapy in the rat brainstem with multiple catheters: a feasibility study.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 13 citations in OpenAlex.
- Advances in Molecular Imaging of Locally Delivered Targeted Therapeutics for Central Nervous System Tumors.International journal of molecular sciences · 2017Review
- Convection-enhanced drug delivery for gliomas.Surgical neurology international · 2015Article
- Interstitial chemotherapy for malignant glioma: Future prospects in the era of multimodal therapy.Surgical neurology international · 2015Article
- Single compartment drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2014Review
- Convection-enhanced delivery of topotecan into diffuse intrinsic brainstem tumors in children.Journal of neurosurgery. Pediatrics · 2013Article
- The effects of temozolomide delivered by prolonged intracerebral microinfusion against the rat brainstem GBM allograft model.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2012Article
- Convection enhanced delivery of carboplatin in combination with radiotherapy for the treatment of brain tumors.Journal of neuro-oncology · 2011Article
- Neurological grading, survival, MR imaging, and histological evaluation in the rat brainstem glioma model.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2009Article
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7 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
objectsTechnical aspects of local chemotherapy in inoperable brainstem gliomas by convection-enhanced delivery (CED) are still under experimental considerations. In this study, we characterize the feasibility of multiple cannula placements in the rat brainstem. MATERIALS AND
methodsIn 38 male Fisher rats, up to three guided screws were positioned in burr holes paramedian at 2.5 mm anterior and posterior to as well as at the lambdoid suture. Using Alzettrade mark pumps (1 microl/h flow rate over 7 days) either vehicle (5% dextrose) or 0.1 mg carboplatin was delivered via one, two, or three cannulas, respectively. During cannula insertion, electrocardiogram and respiratory rate was monitored. All rats were subsequently evaluated neurologically for 8 days. For drug distribution in coronal sections, the brain tissue concentration of platinum was measured. HE staining was used to evaluate the local site of drug delivery. Heart and respiratory rate remained within normal range during surgical procedure. Neurological scoring showed only mild neurological impairment in the groups receiving two or three cannulas, which resolved after vehicle delivery. However, after carboplatin delivery, this deficit remained unchanged. Drug distribution was more homogeneous in the three cannula group. Histological slices visualized edematous changes at the sight of cannula placement.
conclusionThe unilateral application of up to three cannulas in the brainstem of rats for local drug delivery studies is feasible. The remaining neurological deficit in carboplatin-treated animals underlines the need of low toxicity drugs for CED in the brainstem.
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