ArticleInternational journal of biological sciences2008
PPAR gamma agonist normalizes glomerular filtration rate, tissue levels of homocysteine, and attenuates endothelial-myocyte uncoupling in alloxan induced diabetic mice.
Article in International journal of biological sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 19 citations in OpenAlex.
- Guidelines for diet-induced models of cardiometabolic syndrome.American journal of physiology. Heart and circulatory physiology · 2025Review
- Elevated homocysteine level as an indicator for chronic kidney disease in community-dwelling middle-aged and elderly populations in Taiwan: A community-based cross-sectional study.Frontiers in medicine · 2022Article
- Mechanism of Blood-Heart-Barrier Leakage: Implications for COVID-19 Induced Cardiovascular Injury.International journal of molecular sciences · 2021Article
- Protective Effects and Metabolic Regulatory Mechanisms of Shenyan Fangshuai Recipe on Chronic Kidney Disease in Rats.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Homocysteine and hydrogen sulfide in epigenetic, metabolic and microbiota related renovascular hypertension.Pharmacological research · 2016Review
- Protective Effects of Hydrogen Sulfide in the Ageing Kidney.Oxidative medicine and cellular longevity · 2016Article
- Combined effect of hydrogen sulphide donor and losartan in experimental diabetic nephropathy in rats.Journal of diabetes and metabolic disorders · 2015Article
- Association between plasma homocysteine and progression of early nephropathy in type 2 diabetic patients.International journal of clinical and experimental medicine · 2015Article
- Chronic hyperhomocysteinemia causes vascular remodelling by instigating vein phenotype in artery.Archives of physiology and biochemistry · 2011Article
- Homocysteine inhibits adipogenesis in 3T3-L1 preadipocytes.Experimental biology and medicine (Maywood, N.J.) · 2011Article
- Cystathionine β-synthase and cystathionine γ-lyase double gene transfer ameliorate homocysteine-mediated mesangial inflammation through hydrogen sulfide generation.American journal of physiology. Cell physiology · 2011Article
- Synergism in hyperhomocysteinemia and diabetes: role of PPAR gamma and tempol.Cardiovascular diabetology · 2010Article
- Homocysteine and Hypertension in Diabetes: Does PPARgamma Have a Regulatory Role?PPAR research · 2010Article
- Hydrogen sulfide ameliorates hyperhomocysteinemia-associated chronic renal failure.American journal of physiology. Renal physiology · 2009Article
- Ciglitazone, a PPARgamma agonist, ameliorates diabetic nephropathy in part through homocysteine clearance.American journal of physiology. Endocrinology and metabolism · 2008Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundHomocysteine (Hcy) is an independent cardiovascular risk factor; however, in diabetes, the role of tissue Hcy leading to cardiac dysfunction is unclear.
aimsTo determine whether tissue Hcy caused endothelial-myocyte uncoupling and ventricular dysfunction in diabetes.
methodsDiabetes was created in C57BL/6J male mice by injecting 65 mg/kg alloxan. To reverse diabetic complications, ciglitazone (CZ) was administered in the drinking water. Plasma glucose, Hcy, left ventricular (LV) tissue levels of Hcy and nitric oxide (NO) were measured. Glomerular filtration rate (GFR) was measured by inulin-FITC. Endothelial-myocyte coupling was measured in cardiac rings. In vivo diastolic relaxation and LV diameters were measured by a Millar catheter in LV and by M-mode echocardiography, respectively.
resultsPlasma glucose, GFR and LV tissue Hcy were increased in diabetic mice and were normalized after CZ treatment; whereas, elevated plasma Hcy level remained unchanged with or without CZ treatment. NO levels in the LV were found inversely related to tissue Hcy levels. Attenuated endothelial-myocyte function in diabetic mice was ameliorated by CZ treatment. Cardiac relaxation, the ratio of LV wall thickness to LV diameter was decreased in diabetes, and normalized after CZ treatment.
conclusionCZ normalized LV tissue levels of Hcy and ameliorated endothelial-myocyte coupling; therefore, specifically suggest the association of LV tissue Hcy levels with impair endothelial-myocyte function in diabetes.
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