ReviewBehavioural pharmacology2008
Targeting Homer genes using adeno-associated viral vector: lessons learned from behavioural and neurochemical studies.
Review in Behavioural pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 32 citations in OpenAlex.
- Molecular mechanisms of alcohol's effects on the human body: A review and update.Journal of biochemical and molecular toxicology · 2023Review
- Genomic analyses reveal distinct genetic architectures and selective pressures in buffaloes.GigaScience · 2020Article
- Transgenic Analyses of Homer2 Function Within Nucleus Accumbens Subregions in the Regulation of Methamphetamine Reward and Reinforcement in Mice.Frontiers in psychiatry · 2020Article
- Increased Alcohol-Drinking Induced by Manipulations of mGlu5 Phosphorylation within the Bed Nucleus of the Stria Terminalis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Homer2 within the central nucleus of the amygdala modulates withdrawal-induced anxiety in a mouse model of binge-drinking.Neuropharmacology · 2018Article
- Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice.Nature communications · 2017Article
- Methamphetamine Addiction Vulnerability: The Glutamate, the Bad, and the Ugly.Biological psychiatry · 2017Article
- Behavioral and Neurochemical Phenotyping of Mice Incapable of Homer1a Induction.Frontiers in behavioral neuroscience · 2017Article
- Functional regulation of PI3K-associated signaling in the accumbens by binge alcohol drinking in male but not female mice.Neuropharmacology · 2016Article
- Overexpression of Homer1a in the basal and lateral amygdala impairs fear conditioning and induces an autism-like social impairment.Molecular autism · 2016Article
- Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings.Progress in molecular biology and translational science · 2016Review
- MicroRNAs in Schizophrenia: Implications for Synaptic Plasticity and Dopamine-Glutamate Interaction at the Postsynaptic Density. New Avenues for Antipsychotic Treatment Under a Theranostic Perspective.Molecular neurobiology · 2015Review
- Homer2 within the nucleus accumbens core bidirectionally regulates alcohol intake by both P and Wistar rats.Alcohol (Fayetteville, N.Y.) · 2015Article
- Homer protein-metabotropic glutamate receptor binding regulates endocannabinoid signaling and affects hyperexcitability in a mouse model of fragile X syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Strong selection for behavioural resilience in Australian stock working dogs identified by selective sweep analysis.Canine genetics and epidemiology · 2015Article
- Synaptic depression via mGluR1 positive allosteric modulation suppresses cue-induced cocaine craving.Nature neuroscience · 2014Article
- Article
- Imbalances in prefrontal cortex CC-Homer1 versus CC-Homer2 expression promote cocaine preference.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Homers at the Interface between Reward and Pain.Frontiers in psychiatry · 2013Article
- Signaling pathways mediating alcohol effects.Current topics in behavioral neurosciences · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Over a decade of in-vitro data support a critical role for members of the Homer family of postsynaptic scaffolding proteins in regulating the functional architecture of glutamate synapses. Earlier studies of Homer knockout mice indicated a necessary role for Homer gene products in normal mesocorticolimbic glutamate transmission and behaviours associated therewith. The advent of adeno-associated viral vectors carrying cDNA for, or short hairpin RNA against, specific Homer isoforms enabled the site-directed targeting of Homers to neurons in the brain. This approach has allowed our groups to address developmental issues associated with conventional knockout mice, to confirm active roles for distinct Homer isoforms in regulating glutamate transmission in vivo, as well as in mediating a variety of behavioural processes. This review summarizes the existing data derived from our studies using adeno-associated viral vector-mediated neuronal targeting of Homer in rodents, implicating this family of proteins in drug and alcohol addiction, learning/memory and emotional processing.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.