ArticleGenetics2008
Bayesian quantitative trait loci mapping for multiple traits.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Single- and multiple-trait quantitative trait locus analyses for seed oil and protein contents of soybean populations with advanced breeding line background.Molecular breeding : new strategies in plant improvement · 2024Article
- Bayesian mixed models for longitudinal genetic data: theory, concepts, and simulation studies.Genomics & informatics · 2022Article
- Genetic Bases of Complex Traits: From Quantitative Trait Loci to Prediction.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Pleiotropic Loci Associated With Foot Disorders and Common Periparturient Diseases in Holstein Cattle.Frontiers in genetics · 2021Article
- Comparison ofFrontiers in genetics · 2019Article
- Genomic Signatures of Adaptation to a Precipitation Gradient in Nigerian Sorghum.G3 (Bethesda, Md.) · 2018Article
- Simultaneous estimation of QTL parameters for mapping multiple traits.Journal of genetics · 2018Article
- A rare-variant test for high-dimensional data.European journal of human genetics : EJHG · 2017Article
- Novel Resampling Improves Statistical Power for Multiple-Trait QTL Mapping.G3 (Bethesda, Md.) · 2017Article
- MARV: a tool for genome-wide multi-phenotype analysis of rare variants.BMC bioinformatics · 2017Article
- Next Generation Mapping of Enological Traits in an F2 Interspecific Grapevine Hybrid Family.PloS one · 2016Article
- A multivariate genome-wide association analysis of 10 LDL subfractions, and their response to statin treatment, in 1868 Caucasians.PloS one · 2015Article
- Integrative Bayesian variable selection with gene-based informative priors for genome-wide association studies.BMC genetics · 2014Article
- Multiple-trait genome-wide association study based on principal component analysis for residual covariance matrix.Heredity · 2014Article
- Dissecting dynamic genetic variation that controls temporal gene response in yeast.PLoS computational biology · 2014Article
- Article
- Efficient multivariate linear mixed model algorithms for genome-wide association studies.Nature methods · 2014Article
- Identification of QTLs for Resistance to Sclerotinia sclerotiorum in Carioca Common Bean by the Moving Away Method.ISRN molecular biology · 2014Article
- Article
- Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli.Nature biotechnology · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Most quantitative trait loci (QTL) mapping experiments typically collect phenotypic data on multiple correlated complex traits. However, there is a lack of a comprehensive genomewide mapping strategy for correlated traits in the literature. We develop Bayesian multiple-QTL mapping methods for correlated continuous traits using two multivariate models: one that assumes the same genetic model for all traits, the traditional multivariate model, and the other known as the seemingly unrelated regression (SUR) model that allows different genetic models for different traits. We develop computationally efficient Markov chain Monte Carlo (MCMC) algorithms for performing joint analysis. We conduct extensive simulation studies to assess the performance of the proposed methods and to compare with the conventional single-trait model. Our methods have been implemented in the freely available package R/qtlbim (http://www.qtlbim.org), which greatly facilitates the general usage of the Bayesian methodology for unraveling the genetic architecture of complex traits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.