ArticleGenetics2008
Cut thy neighbor: cyclic birth and death of recombination hotspots via genetic conflict.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Analysis of the impact of gene evolution on reproductive effects reveals prevalent sexual and germline-soma conflicts.Nature ecology & evolution · 2026Article
- Why recombination hotspots?PLoS genetics · 2026Review
- Hotspots for Initiation of Meiotic Recombination.Frontiers in genetics · 2018Review
- Bridge-Induced Translocation betweenFrontiers in oncology · 2017Article
- Nonparadoxical evolutionary stability of the recombination initiation landscape in yeast.Science (New York, N.Y.) · 2015Article
- Distribution of recombination hotspots in the human genome--a comparison of computer simulations with real data.PloS one · 2013Article
- Genetic crossovers are predicted accurately by the computed human recombination map.PLoS genetics · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most recombination takes place in numerous, localized regions called hotspots. However, empirical evidence indicates that nascent hotspots are susceptible to removal due to biased gene conversion, so it is paradoxical that they should be so widespread. Previous modeling work has shown that hotspots can evolve due to genetic drift overpowering their intrinsic disadvantage. Here we synthesize recent theoretical and empirical results to show how natural selection can favor hotspots. We propose that hotspots are part of a cycle of antagonistic coevolution between two tightly linked chromosomal regions: an inducer region that initiates recombination during meiosis by cutting within a nearby region of DNA and the cut region itself, which can evolve to be resistant to cutting. Antagonistic coevolution between inducers and their cut sites is driven by recurrent episodes of Hill-Robertson interference, genetic hitchhiking, and biased gene conversion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.