ArticleGenetics2008
Developmental and environmental signals induce distinct histone acetylation profiles on distal and proximal promoter elements of the C4-Pepc gene in maize.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- ZmELP1, an Elongator complex subunit, is required for the maintenance of histone acetylation and RNA Pol II phosphorylation in maize kernels.Plant biotechnology journal · 2024Article
- C4 Phosphoenolpyruvate Carboxylase: Evolution and transcriptional regulation.Genetics and molecular biology · 2024Article
- Cis-regulatory sequences in plants: Their importance, discovery, and future challenges.The Plant cell · 2022Review
- NuA4 and H2A.Z control environmental responses and autotrophic growth in Arabidopsis.Nature communications · 2022Article
- Network and epigenetic characterization of subsets of genes specifically expressed in maize bundle sheath cells.Computational and structural biotechnology journal · 2022Article
- Epigenomic landscape and epigenetic regulation in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Review
- H3K4/K9 acetylation and Lr28-mediated expression of six leaf rust responsive genes in wheat (Triticum aestivum).Molecular genetics and genomics : MGG · 2019Article
- Histone Acetylation Modifications Affect Tissue-Dependent Expression of Poplar Homologs of CFrontiers in plant science · 2017Article
- Regulation of transcription by the Arabidopsis UVR8 photoreceptor involves a specific histone modification.Plant molecular biology · 2016Article
- Analysis of gene expression and histone modification between C4 and non-C4 homologous genes of PPDK and PCK in maize.Photosynthesis research · 2016Article
- Photosynthetic Genes and Genes Associated with the C4 Trait in Maize Are Characterized by a Unique Class of Highly Regulated Histone Acetylation Peaks on Upstream Promoters.Plant physiology · 2015Article
- Major alterations in transcript profiles between C3-C4 and C4 photosynthesis of an amphibious species Eleocharis baldwinii.Plant molecular biology · 2014Article
- Signal integration on plant promoters: a case study in maize.Plant signaling & behavior · 2013Article
- A Common histone modification code on C4 genes in maize and its conservation in Sorghum and Setaria italica.Plant physiology · 2013Article
- Regulation of the fruit-specific PEP carboxylase SlPPC2 promoter at early stages of tomato fruit development.PloS one · 2012Article
- Core promoter acetylation is not required for high transcription from the phosphoenolpyruvate carboxylase promoter in maize.Epigenetics & chromatin · 2009Article
- Dynamic landscapes of four histone modifications during deetiolation in Arabidopsis.The Plant cell · 2009Article
- Mass spectrometry analysis of the variants of histone H3 and H4 of soybean and their post-translational modifications.BMC plant biology · 2009Article
- Chromatin and DNA modifications in the Opaque2-mediated regulation of gene transcription during maize endosperm development.The Plant cell · 2009Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The maize C(4)-Pepc gene is expressed in an organ- and cell-type-specific manner, inducible by light and modulated by nutrient availability and the metabolic state of the cell. We studied the contribution of histone acetylation at five lysine residues to the integration of these signals into a graduated promoter response. In roots and coleoptiles, where the gene is constitutively inactive, three of the five lysines were acetylated and the modifications showed unique patterns with respect to their distribution on the gene. A similar pattern was observed in etiolated leaves, where the gene is poised for activation by light. Here, illumination selectively induced the acetylation of histone H4 lysine 5 and histone H3 lysine 9 in both the promoter and the transcribed region, again with unique distribution patterns. Induction was independent of transcription and fully reversible in the dark. Nitrate and hexose availability modulated acetylation of all five lysines restricted to a distal promoter region, whereas proximal promoter acetylation was highly resistant to these stimuli. Our data suggest that light induction of acetylation is controlled by regulating HDAC activity, whereas metabolic signals regulate HAT activity. Acetylation turnover rates were high in the distal promoter and the transcribed regions, but low on the proximal promoter. On the basis of these results, we propose a model with three levels of stimulus-induced histone modifications that collectively adjust promoter activity. The results support a charge neutralization model for the distal promoter and a stimulus-mediated, but transcription-independent, histone acetylation pattern on the core promoter, which might be part of a more complex histone code.
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