ArticleBiophysical journal2008
Structure and interactions of aggrecans: statistical thermodynamic approach.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 55 citations in OpenAlex.
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- The impact of charge regulation and ionic intranuclear environment on the nucleosome core particle.The Journal of chemical physics · 2024Article
- The Impact of Charge Regulation and Ionic Intranuclear Environment on the Nucleosome Core Particle.bioRxiv : the preprint server for biology · 2024Article
- Bottlebrush Networks: A Primer for Advanced Architectures.Angewandte Chemie (International ed. in English) · 2024Review
- Computational insights into the substrate recognition mechanism of cartilage extracellular matrix degradation.Computational and structural biotechnology journal · 2021Article
- Single-Molecule Stretching Shows Glycosylation Sets Tension in the Hyaluronan-Aggrecan Bottlebrush.Biophysical journal · 2020Article
- Theoretical Modeling of Chemical Equilibrium in Weak Polyelectrolyte Layers on Curved Nanosystems.Polymers · 2020Review
- Microscale mapping of extracellular matrix elasticity of mouse joint cartilage: an approach to extracting bulk elasticity of soft matter with surface roughness.Soft matter · 2018Article
- Protamine neutralizes chondroitin sulfate proteoglycan-mediated inhibition of oligodendrocyte differentiation.PloS one · 2017Article
- Article
- Notochord Cells in Intervertebral Disc Development and Degeneration.Journal of developmental biology · 2016Article
- Detection of low back pain using pH level-dependent imaging of the intervertebral disc using the ratio of R1ρ dispersion and -OH chemical exchange saturation transfer (RROC).Magnetic resonance in medicine · 2015Article
- Multiscale mechanics of articular cartilage: potentials and challenges of coupling musculoskeletal, joint, and microscale computational models.Annals of biomedical engineering · 2012Review
- Proteoglycan metabolism, cell death and Kashin-Beck disease.Glycoconjugate journal · 2012Review
- Aggrecan, an unusual polyelectrolyte: review of solution behavior and physiological implications.Acta biomaterialia · 2012Review
- Nanomechanics of the Cartilage Extracellular Matrix.Annual review of materials research · 2011Article
- How the projection domains of NF-L and alpha-internexin determine the conformations of NF-M and NF-H in neurofilaments.European biophysics journal : EBJ · 2010Article
- Molecular dynamics simulations of end-grafted centipede-like polymers with stiff charged side chains.The European physical journal. E, Soft matter · 2010Article
- Ions in hyaluronic acid solutions.The Journal of chemical physics · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Weak polyelectrolytes tethered to cylindrical surfaces are investigated using a molecular theory. These polymers form a model system to describe the properties of aggrecan molecules, which is one of the main components of cartilage. We have studied the structural and thermodynamical properties of two interacting aggrecans with a molecular density functional theory that incorporates the acid-base equilibrium as well as the molecular properties: including conformations, size, shape, and charge distribution of all molecular species. The effect of acidity and salt concentration on the behavior is explored in detail. The repulsive interactions between two cylindrical-shaped aggrecans are strongly influenced by both the salt concentration and the pH. With increasing acidity, the polyelectrolytes of the aggrecan acquire charge and with decreasing salt concentration those charges become less screened. Consequently the interactions increase in size and range with increasing acidity and decreasing salt concentration. The size and range of the forces offers a possible explanation to the aggregation behavior of aggrecans and for their ability to resist compressive forces in cartilage. Likewise, the interdigitation of two aggrecan molecules is strongly affected by the salt concentration as well as the pH. With increasing pH, the number of charges increases, causing the repulsions between the polymers to increase, leading to a lower interdigitation of the two cylindrical polymer layers of the aggrecan molecules. The low interdigitation in charged polyelectrolytes layers provides an explanation for the good lubrication properties of polyelectrolyte layers in general and cartilage in particular.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.