ArticleBiophysical journal2008
Site-specific effects of compression on macromolecular diffusion in articular cartilage.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- Strain-Dependent Diffusivity of Small and Large Molecules in Meniscus.Journal of biomechanical engineering · 2022Article
- EFFECTS OF SOLUTE SIZE AND TISSUE COMPOSITION ON MOLECULAR AND MACROMOLECULAR DIFFUSIVITY IN HUMAN KNEE CARTILAGE.Osteoarthritis and cartilage open · 2020Article
- On the characterization of interstitial fluid flow in the skeletal muscle endomysium.Journal of the mechanical behavior of biomedical materials · 2020Article
- A versatile microfluidic device for multiple ex vivo/in vitro tissue assays unrestrained from tissue topography.Microsystems & nanoengineering · 2020Article
- Evaluation of the effects of pregabalin on chondrocyte proliferation andArchives of medical science : AMS · 2018Article
- Direct Quantification of Solute Diffusivity in Agarose and Articular Cartilage Using Correlation Spectroscopy.Annals of biomedical engineering · 2017Article
- An Experimental and Finite Element Protocol to Investigate the Transport of Neutral and Charged Solutes across Articular Cartilage.Journal of visualized experiments : JoVE · 2017Article
- Assessing the negative impact of phenyl alkanoic acid derivative, a frequently prescribed drug for the suppression of pain and inflammation, on the differentiation and proliferation of chondrocytes.Journal of orthopaedic surgery and research · 2016Article
- Biological and MRI characterization of biomimetic ECM scaffolds for cartilage tissue regeneration.Biomaterials · 2015Article
- Quantifying load-induced solute transport and solute-matrix interaction within the osteocyte lacunar-canalicular system.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013Article
- Altered trabecular bone structure and delayed cartilage degeneration in the knees of collagen VI null mice.PloS one · 2012Article
- Spinal facet joint biomechanics and mechanotransduction in normal, injury and degenerative conditions.Journal of biomechanical engineering · 2011Review
- Measurement of diffusion in articular cartilage using fluorescence correlation spectroscopy.BMC biotechnology · 2011Article
- Simultaneous measurement of anisotropic solute diffusivity and binding reaction rates in biological tissues by FRAP.Annals of biomedical engineering · 2011Article
- Validation of theoretical framework explaining active solute uptake in dynamically loaded porous media.Journal of biomechanics · 2010Article
- Tissue formation and vascularization in anatomically shaped human joint condyle ectopically in vivo.Tissue engineering. Part A · 2009Article
- In situ measurement of transport between subchondral bone and articular cartilage.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Articular cartilage is the connective tissue that lines joints and provides a smooth surface for joint motion. Because cartilage is avascular, molecular transport occurs primarily via diffusion or convection, and cartilage matrix structure and composition may affect diffusive transport. Because of the inhomogeneous compressive properties of articular cartilage, we hypothesized that compression would decrease macromolecular diffusivity and increase diffusional anisotropy in a site-specific manner that depends on local tissue strain. We used two fluorescence photobleaching methods, scanning microphotolysis and fluorescence imaging of continuous point photobleaching, to measure diffusion coefficients and diffusional anisotropy of 70 kDa dextran in cartilage during compression, and measured local tissue strain using texture correlation. For every 10% increase in normal strain, the fractional change in diffusivity decreased by 0.16 in all zones, and diffusional anisotropy increased 1.1-fold in the surface zone and 1.04-fold in the middle zone, and did not change in the deep zone. These results indicate that inhomogeneity in matrix structure and composition may significantly affect local diffusive transport in cartilage, particularly in response to mechanical loading. Our findings suggest that high strains in the surface zone significantly decrease diffusivity and increase anisotropy, which may decrease transport between cartilage and synovial fluid during compression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.