ArticleThe American journal of clinical nutrition2008
Evidence for genetic regulation of vitamin D status in twins with multiple sclerosis.
Article in The American journal of clinical nutrition, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
90 citing papers in PubMed, 5 syntheses or guidelines pooled it, 231 citations in OpenAlex.
- Genetic Variants Shaping Inter-individual Differences in Response to Dietary Intakes-A Narrative Review of the Case of Vitamins.Frontiers in nutrition · 2020Pooled it
- The Association Between Genetic Polymorphism rs703842 in CYP27B1 and Multiple Sclerosis: A Meta-Analysis.Medicine · 2016Pooled it
- Systematic Review of the Relationship between Vitamin D and Parkinson's Disease.Journal of Parkinson's disease · 2016Pooled it
- Does vitamin D affect risk of developing autoimmune disease?: a systematic review.Seminars in arthritis and rheumatism · 2011Pooled it
- Hip fracture risk in relation to vitamin D supplementation and serum 25-hydroxyvitamin D levels: a systematic review and meta-analysis of randomised controlled trials and observational studies.BMC public health · 2010Pooled it
- Influence of genetic variation in the vitamin D pathway on plasma 25-hydroxyvitamin DCancer causes & control : CCC · 2019Trial
- Genomic Response to Vitamin D Supplementation in the Setting of a Randomized, Placebo-Controlled Trial.EBioMedicine · 2018Trial
- CYP24A1 and CYP27B1 Polymorphisms, Concentrations of Vitamin D Metabolites, and Odds of Colorectal Adenoma Recurrence.Nutrition and cancer · 2015Trial
- Vitamin D Receptor Fok-I polymorphism modulates diabetic host response to vitamin D intake: need for a nutrigenetic approach.Diabetes care · 2013Trial
- What is needed to keep persons with multiple sclerosis vitamin D-sufficient throughout the year?Journal of neurology · 2013Trial
- Genome-wide association analysis of circulating vitamin D levels in children with asthma.Human genetics · 2012Trial
- Maternal vitamin D and genetic variants determine cord blood vitamin D levels in newborn.Pediatric research · 2026Article
- The association of VDR gene polymorphisms with serum vitamin D levels and injury predisposition in elite athletes of Kazakhstan.European journal of applied physiology · 2026Article
- FokI Polymorphism of theNutrients · 2025Article
- Article
- Prevalence and Progression of Vitamin D Deficiency in Greater Beirut and Mount Lebanon From 2013 to 2022: An Analysis of 19,452 Adults.Journal of clinical laboratory analysis · 2025Article
- The protective role of vitamin D in BNT162b2 vaccine-related acute myocarditis.Frontiers in immunology · 2025Article
- Article
- The impact of genetic variants related to vitamin D and autoimmunity: A systematic review.Heliyon · 2024Article
- Review
30 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMultiple sclerosis (MS) risk is determined by both genes and environment. One of the most striking features of MS is its geographic distribution, particularly the pattern of high MS frequency in areas with low sunlight exposure, the main inducer of vitamin D synthesis. Recent epidemiologic, experimental, and clinical evidence support an effect for low environmental supplies of vitamin D in mediating an increased susceptibility to MS.
objectivesWe 1) examined the association of serum 25-hydroxy-vitaminD [25(OH)D] concentrations and MS status and 2) assessed the genetic contribution to serum 25(OH)D concentrations and tested for its association with genetic variants in 2 candidate genes [vitamin D receptor and 1-alpha-hydroxylase (CYP27B1)].
designWe used a twin study approach, comprising adult pairs identified from the longitudinal population-based Canadian Collaborative Project on Genetic Susceptibility to MS. Monozygotic (MZ; n = 40) and dizygotic (DZ; n = 59) pairs, both concordant and discordant for MS, were studied. End-of-winter serum 25(OH)D concentrations were measured by radioimmunoassay, and genotypes were assessed by single nucleotide polymorphism (SNP) assay.
resultsSerum concentrations of 25(OH)D were highly correlated in MS-concordant pairs (r = 0.83, P < 0.001), but they were not significantly associated with having the disease (P = 0.4) when analyzed by logistic regression. Intraclass correlation for 25(OH)D concentration was significantly greater in MZ pairs (MZ, r: 0.71 > DZ r: 0.32, P = 0.006). Significant associations of 2 CYP27B1 SNP variants and 25(OH)D concentrations were observed.
conclusionThe findings indicate important genetic influences on regulation of seasonal circulating 25(OH)D concentrations in MS twins.
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