ArticlePsycho-oncology2008
Psychological functioning in persons considering genetic counseling and testing for Li-Fraumeni syndrome.
Article in Psycho-oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Chatbot Intervention and Cancer Risk Knowledge in Adolescents and Young Adults With Cancer Predisposition: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Psychosocial morbidity in TP53 mutation carriers: is whole-body cancer screening beneficial?Familial cancer · 2017Trial
- Making Sense of Missense: Assessing and Incorporating the Functional Impact of Constitutional Genetic Testing.Children (Basel, Switzerland) · 2025Article
- Health-related quality of life and fear of progression in individuals with Li-Fraumeni syndrome.Journal of genetic counseling · 2025Article
- Psychological Impact ofCancers · 2022Article
- Fear of cancer recurrence in patients undergoing germline genome sequencing.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Family Identity and Roles in the Context of Li-Fraumeni Syndrome: "No One's Like Us Mutants".Health & social work · 2021Article
- Waiting and "weighted down": the challenge of anticipatory loss for individuals and families with Li-Fraumeni Syndrome.Familial cancer · 2020Article
- Psychosocial effects of whole-body MRI screening in adult high-risk pathogenicJournal of medical genetics · 2020Article
- Should pretest genetic counselling be required for patients pursuing genomic sequencing? Results from a survey of participants in a large genomic implementation study.Journal of medical genetics · 2019Article
- TP53 germline mutation testing in early-onset breast cancer: findings from a nationwide cohort.Familial cancer · 2019Article
- Genetic counselling of young women with breast cancer for Li-Fraumeni syndrome: a nationwide survey on the experiences and attitudes of genetics professionals.Familial cancer · 2019Article
- Next generation sequencing is informing phenotype: a TP53 example.Familial cancer · 2018Article
- The psychosocial effects of the Li-Fraumeni Education and Early Detection (LEAD) program on individuals with Li-Fraumeni syndrome.Genetics in medicine : official journal of the American College of Medical Genetics · 2017Article
- Easing the Burden: Describing the Role of Social, Emotional and Spiritual Support in Research Families with Li-Fraumeni Syndrome.Journal of genetic counseling · 2016Article
- Tumor protein p53 (TP53) testing and Li-Fraumeni syndrome : current status of clinical applications and future directions.Molecular diagnosis & therapy · 2013Review
- On averages and peaks: how do people integrate attitudes about multiple diseases to reach a decision about multiplex genetic testing?Medical decision making : an international journal of the Society for Medical Decision Making · 2013Article
- Factors influencing cancer risk perception in high risk populations: a systematic review.Hereditary cancer in clinical practice · 2011Article
- Li-fraumeni syndrome.Genes & cancer · 2011Article
- Couples coping with screening burden and diagnostic uncertainty in Li-Fraumeni syndrome: Connection versus independence.Journal of psychosocial oncologyArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveLi-Fraumeni syndrome (LFS) confers an increased risk of multiple types of cancer in both children and adults. Clinical genetic testing for deleterious germline p53 gene mutations can identify most LFS-affected families. We evaluated factors associated with cancer-specific distress and perceived self-efficacy in coping with a positive genetic test result among persons at risk of having deleterious p53 mutations.
methodsOne hundred thirty-five persons from 15 LFS-affected families were invited to take part in a study that offered p53 genetic counseling and testing and to complete psychosocial measures.
resultsParticipants (n=92) were more likely to be younger and female than nonparticipants (n=43). In multivariate analyses, greater cancer-specific distress was associated with having a lower quality of life, a higher perceived risk of having a p53 mutation, no personal history of cancer and a greater number of first degree relatives (FDRs) affected with cancer. Lower perceived self-efficacy in coping with a positive test result was associated with greater cancer worry, higher decisional conflict about p53 testing and having no personal history of cancer.
conclusionsIndividual perceptions about cancer risk and p53 genetic testing, as well as personal experience with FDRs' cancer diagnoses and deaths, should be addressed during the counseling and testing process for LFS-affected families.
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