ArticleEuropean journal of applied physiology2008
Anaerobic exercise reduces tumor growth, cancer cachexia and increases macrophage and lymphocyte response in Walker 256 tumor-bearing rats.
Article in European journal of applied physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Can Exercise Counteract Cancer Cachexia? A Systematic Literature Review and Meta-Analysis.Integrative cancer therapiesPooled it
- The Influence of an Acute Endurance Intervention on Breast Cancer Cell Growth-A Pilot Study.International journal of molecular sciences · 2025Article
- The Influence of Exercise on Cancer Risk, the Tumor Microenvironment and the Treatment of Cancer.Sports medicine (Auckland, N.Z.) · 2024Review
- Effects of Exercise-Induced Changes in Myokine Expression on the Tumor Microenvironment.Sports medicine international open · 2024Review
- Novel Role of CETP in Macrophages: Reduction of Mitochondrial Oxidants Production and Modulation of Cell Immune-Metabolic Profile.Antioxidants (Basel, Switzerland) · 2022Article
- Mild Mitochondrial Uncoupling Decreases Experimental Atherosclerosis, A Proof of Concept.Journal of atherosclerosis and thrombosis · 2022Article
- Insulin and cancer: a tangled web.The Biochemical journal · 2022Review
- Exercise modulates polarization of TAMs and expression of related immune checkpoints in mice with lung cancer.Journal of Cancer · 2022Article
- Reframing How Physical Activity Reduces The Incidence of Clinically-Diagnosed Cancers: Appraising Exercise-Induced Immuno-Modulation As An Integral Mechanism.Frontiers in oncology · 2022Review
- Article
- Molecular Mechanisms of Exercise on Cancer: A Bibliometrics Study and Visualization AnalysisFrontiers in molecular biosciences · 2021Review
- Exercise Oncology and Immuno-Oncology; A (Future) Dynamic Duo.International journal of molecular sciences · 2020Review
- Effects of Exercise on the Tumour Microenvironment.Advances in experimental medicine and biology · 2020Review
- NexrutinePhysiological reports · 2019Article
- Resveratrol Action on Lipid Metabolism in Cancer.International journal of molecular sciences · 2019Review
- Physical exercise alters hepatic morphology of low-density lipoprotein receptor knockout ovariectomized mice.Medical molecular morphology · 2019Article
- Impact of Physical Exercise on Growth and Progression of Cancer in Rodents-A Systematic Review and Meta-Analysis.Frontiers in oncology · 2019Article
- Cancer and Exercise: Warburg Hypothesis, Tumour Metabolism and High-Intensity Anaerobic Exercise.Sports (Basel, Switzerland) · 2018Review
- Spontaneous Physical Activity Downregulates Pax7 in Cancer Cachexia.Stem cells international · 2016Article
- The effect of physical training on the N-methyl-N-nitrosourea-induced mammary carcinogenesis of Sprague-Dawley rats.Experimental biology and medicine (Maywood, N.J.) · 2015Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here, we investigated the effect of jump exercise on tumor growth, cancer cachexia, lymphocyte proliferation and macrophage function in Walker 256 tumor-bearing rats. Male Wistar rats (60 days) were divided into sedentary (C) and exercised (E) groups. Jump training consisted of six sets of 10 jumps in water with overload of 50% of body mass with 1 min of resting, four times per week for 8 weeks. After 6 weeks of training, half of each group was inoculated with 2 x 10(7) cells of Walker 256 tumor. Sedentary tumor-bearing and exercised tumor-bearing are referred to as T and TE, respectively. Tumor weight in the T group was 25 g. These animals display loss of weight, hypertriacylglycerolemia, hyperlacticidemia, depletion of glycogen stores and increase in PIF expression. Jump exercise (TE) induced a significant lower tumor weight, preserves liver glycogen stores, partly prevented the hypertriacylglycerolemia, hyperlacticidemia and, prevented the fall in body weight and reduced PIF expression. Lymphocyte was increased by tumor burden (T) and was higher by including exercise (TE). The same was observed regarding phagocytosis and lysosomal volume. Anaerobic exercise decreases tumor growth, cancer cachexia and increases innate and adaptative immune function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.