ArticlePLoS genetics2008
E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage.
Article in PLoS genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 66 citations in OpenAlex.
- Plastic Fly: WhatInternational journal of molecular sciences · 2024Article
- Wnt signaling modulates the response to DNA damage in the Drosophila wing imaginal disc by regulating the EGFR pathway.PLoS biology · 2024Article
- Cell proliferation and Notch signaling coordinate the formation of epithelial folds in the Drosophila leg.Development (Cambridge, England) · 2024Article
- Article
- Coordination between cell proliferation and apoptosis after DNA damage in Drosophila.Cell death and differentiation · 2022Article
- Regulation and coordination of the different DNA damage responses inFrontiers in cell and developmental biology · 2022Review
- Chk2-p53 and JNK in irradiation-induced cell death of hematopoietic progenitors and differentiated cells in Drosophila larval lymph gland.Biology open · 2021Article
- The Jieduan-Niwan (JDNW) Formula Ameliorates Hepatocyte Apoptosis: A Study of the Inhibition of E2F1-Mediated Apoptosis Signaling Pathways in Acute-on-Chronic Liver Failure (ACLF) Using Rats.Drug design, development and therapy · 2021Article
- Position Effects Influence Transvection inGenetics · 2019Article
- Characterization of TNF-induced cell death in Drosophila reveals caspase- and JNK-dependent necrosis and its role in tumor suppression.Cell death & disease · 2019Article
- Role of p53 isoforms in the DNA damage response during Drosophila oogenesis.Scientific reports · 2019Article
- Article
- A Cut/cohesin axis alters the chromatin landscape to facilitate neuroblast death.Development (Cambridge, England) · 2019Article
- Ultraspiracle-independent anti-apoptotic function of ecdysone receptors is required for the survival of larval peptidergic neurons via suppression of grim expression in Drosophila melanogaster.Apoptosis : an international journal on programmed cell death · 2019Article
- Tango7 regulates cortical activity of caspases during reaper-triggered changes in tissue elasticity.Nature communications · 2017Article
- Drosophila Wnt and STAT Define Apoptosis-Resistant Epithelial Cells for Tissue Regeneration after Irradiation.PLoS biology · 2016Article
- Different cell cycle modifications repress apoptosis at different steps independent of developmental signaling in Drosophila.Molecular biology of the cell · 2016Article
- Corp Regulates P53 in Drosophila melanogaster via a Negative Feedback Loop.PLoS genetics · 2015Article
- Suppression of induced but not developmental apoptosis in Drosophila by Ayurvedic Amalaki Rasayana and Rasa-Sindoor.Journal of biosciences · 2015Article
- Emerging links between E2F control and mitochondrial function.Cancer research · 2015Review
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
In mammalian cells, RB/E2F and p53 are intimately connected, and crosstalk between these pathways is critical for the induction of cell cycle arrest or cell death in response to cellular stresses. Here we have investigated the genetic interactions between RBF/E2F and p53 pathways during Drosophila development. Unexpectedly, we find that the pro-apoptotic activities of E2F and p53 are independent of one another when examined in the context of Drosophila development: apoptosis induced by the deregulation of dE2F1, or by the overexpression of dE2F1, is unaffected by the elimination of dp53; conversely, dp53-induced phenotypes are unaffected by the elimination of dE2F activity. However, dE2F and dp53 converge in the context of a DNA damage response. Both dE2F1/dDP and dp53 are required for DNA damage-induced cell death, and the analysis of rbf1 mutant eye discs indicates that dE2F1/dDP and dp53 cooperatively promote cell death in irradiated discs. In this context, the further deregulation in the expression of pro-apoptotic genes generates an additional sensitivity to apoptosis that requires both dE2F/dDP and dp53 activity. This sensitivity differs from DNA damage-induced apoptosis in wild-type discs (and from dE2F/dDP-induced apoptosis in un-irradiated rbf1 mutant eye discs) by being dependent on both hid and reaper. These results show that pro-apoptotic activities of dE2F1 and dp53 are surprisingly separable: dp53 is required for dE2F-dependent apoptosis in the response to DNA damage, but it is not required for dE2F-dependent apoptosis caused simply by the inactivation of rbf1.
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