ArticleThe Journal of physiology2008
Hyperoxia prevents exercise-induced intrapulmonary arteriovenous shunt in healthy humans.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 105 citations in OpenAlex.
- Decreased arterial PO2, not O2 content, increases blood flow through intrapulmonary arteriovenous anastomoses at rest.The Journal of physiology · 2016Trial
- Hypoxia and exercise increase the transpulmonary passage of 99mTc-labeled albumin particles in humans.PloS one · 2014Trial
- Intrapulmonary arteriovenous anastomoses in healthy dogs assessed using saline contrast echocardiography and response to oxygen therapy.Journal of veterinary internal medicine · 2026Article
- Beyond the shunt: Divergent insights from hyperoxia testing and contrast echocardiography in adults with pulmonary hypertension.Physiological reports · 2025Article
- Effects of mild hyperbaric oxygen therapy on timing sequence recovery of muscle fatigue in cJournal of exercise science and fitness · 2024Article
- Cerebral air embolism following a hemodialysis session successfully treated with hyperbaric oxygen: a case report.Therapeutic advances in neurological disorders · 2024Article
- Evaluation of intrapulmonary arteriovenous anastomoses before and after oxygen supplementation, using transthoracic agitated saline contrast echocardiography in rescued Korean raccoon dogs.Frontiers in veterinary science · 2024Article
- Hyperoxia-induced stepwise reduction in blood flow through intrapulmonary, but not intracardiac, shunt during exercise.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Effect of Nocturnal Oxygen Therapy on Daytime Pulmonary Hemodynamics in Patients With Chronic Obstructive Pulmonary Disease Traveling to Altitude: A Randomized Controlled Trial.Frontiers in physiology · 2021Article
- Intra-pulmonary arteriovenous anastomoses and pulmonary gas exchange: evaluation by microspheres, contrast echocardiography and inert gas elimination.The Journal of physiology · 2019Article
- Paradoxical Air Embolism Without Patent Foramen Ovale During Craniotomy in the Sitting Position.Cureus · 2019Article
- AltitudeOmics: effect of reduced barometric pressure on detection of intrapulmonary shunt, pulmonary gas exchange efficiency, and total pulmonary resistance.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- The Effects of Hyperoxia on Sea-Level Exercise Performance, Training, and Recovery: A Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2018Review
- Assessing the kinetics of microbubble appearance in cirrhotic patients using transthoracic saline contrast-enhanced echocardiography.Echocardiography (Mount Kisco, N.Y.) · 2017Article
- The Impact of Hyperoxia on Human Performance and Recovery.Sports medicine (Auckland, N.Z.) · 2017Review
- Beta Adrenergic Regulation of Intrapulmonary Arteriovenous Anastomoses in Intact Rat and Isolated Rat Lungs.Frontiers in physiology · 2017Article
- 17β-Estradiol mediates superior adaptation of right ventricular function to acute strenuous exercise in female rats with severe pulmonary hypertension.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Dopamine receptor blockade improves pulmonary gas exchange but decreases exercise performance in healthy humans.The Journal of physiology · 2015Article
- Intrapulmonary arteriovenous anastomoses in humans--response to exercise and the environment.The Journal of physiology · 2015Review
- Hypoxia, not pulmonary vascular pressure, induces blood flow through intrapulmonary arteriovenous anastomoses.The Journal of physiology · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The 100% oxygen (O(2)) technique has been used to detect and quantify right-to-left shunt for more than 50 years. The goal of this study was to determine if breathing 100% O(2) affected intrapulmonary arteriovenous pathways during exercise. Seven healthy subjects (3 females) performed two exercise protocols. In Protocol I subjects performed an incremental cycle ergometer test (60 W + 30 W/2 min; breathing room air, FIO2 = 0.209) and arteriovenous shunting was evaluated using saline contrast echocardiography at each stage. Once significant arteriovenous shunting was documented (bubble score = 2), workload was held constant for the remainder of the protocol and FIO2 was alternated between 1.0 (hyperoxia) and 0.209 (normoxia) as follows: hyperoxia for 180 s, normoxia for 120 s, hyperoxia for 120 s, normoxia for 120 s, hyperoxia for 60 s and normoxia for 120 s. For Protocol II, subjects performed an incremental cycle ergometer test until volitional exhaustion while continuously breathing 100% O(2). In Protocol I, shunting was seen in all subjects at 120-300 W. Breathing oxygen for 1 min reduced shunting, and breathing oxygen for 2 min eliminated shunting in all subjects. Shunting promptly resumed upon breathing room air. Similarly, in Protocol II, breathing 100% O(2) substantially decreased or eliminated exercise-induced arteriovenous shunting in all subjects at submaximal and in 4/7 subjects at maximal exercise intensities. Our results suggest that alveolar hyperoxia prevents or reduces blood flow through arteriovenous shunt pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.