ArticleThe Journal of biological chemistry2008
CLOCK is required for maintaining the circadian rhythms of Opsin mRNA expression in photoreceptor cells.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Effects of circadian clock disruption on gene expression and biological processes in Aedes aegypti.BMC genomics · 2024Article
- Plasticity of cone photoreceptors in adult zebrafish revealed by thyroid hormone exposure.Scientific reports · 2023Article
- Circadian clock organization in the retina: From clock components to rod and cone pathways and visual function.Progress in retinal and eye research · 2023Review
- Long wavelength-sensing cones of zebrafish retina exhibit multiple layers of transcriptional heterogeneity.Frontiers in cellular neuroscience · 2023Article
- Article
- Light-Mediated Inhibition of Colonic Smooth Muscle Constriction and Colonic MotilityFrontiers in physiology · 2021Article
- Daily mitochondrial dynamics in cone photoreceptors.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Ontogenetic expression rhythms of visual opsins in senegalese sole are modulated by photoperiod and light spectrum.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- Dual-Function Analysis of Astaxanthin on Golden Pompano (Frontiers in physiology · 2020Article
- Zebrafish Lacking Circadian GeneFrontiers in behavioral neuroscience · 2018Article
- Elevated cAMP improves signal-to-noise ratio in amphibian rod photoreceptors.The Journal of general physiology · 2017Article
- Integrative analysis of circadian transcriptome and metabolic network reveals the role of de novo purine synthesis in circadian control of cell cycle.PLoS computational biology · 2015Article
- Analysis of a gene regulatory cascade mediating circadian rhythm in zebrafish.PLoS computational biology · 2013Article
- cAMP controls rod photoreceptor sensitivity via multiple targets in the phototransduction cascade.The Journal of general physiology · 2012Article
- Microarray analysis of natural socially regulated plasticity in circadian rhythms of honey bees.Journal of biological rhythms · 2012Article
- Pineal photoreceptor cells are required for maintaining the circadian rhythms of behavioral visual sensitivity in zebrafish.PloS one · 2012Article
- Midkine expression is regulated by the circadian clock in the retina of the zebrafish.Visual neuroscience · 2009Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
In zebrafish, the expression of long-wavelength cone (LC) opsin mRNA fluctuated rhythmically between the day and night. In a 24-h period, expression was high in the afternoon and low in the early morning. This pattern of fluctuation persisted in zebrafish that were kept in constant darkness, suggesting an involvement of circadian clocks. Functional expression of Clock, a circadian clock gene that contributes to the central circadian pacemaker, was found to play an important role in maintaining the circadian rhythms of LC opsin mRNA expression. In zebrafish embryos, in which the translation of Clock was inhibited by anti-Clock morpholinos, the circadian rhythms of LC opsin mRNA expression diminished. CLOCK may regulate the circadian rhythms of LC opsin mRNA expression via cyclic adenosine monophosphate (cAMP)-dependent signaling pathways. In control retinas, the concentration of cAMP was high in the early morning and low in the remainder of the day and night. Inhibition of Clock translation abolished the fluctuation in the concentration of cAMP, thereby diminishing the circadian rhythms of opsin mRNA expression. Transient increase of cAMP concentrations in the early morning (i.e. by treating the embryos with 8-bromo-cAMP) restored the circadian rhythms of LC opsin mRNA expression in morpholino-treated embryos. Together, the data suggest that Clock plays important roles in regulating the circadian rhythms in photoreceptor cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.