ArticleDevelopmental biology2008
Organ-specific requirements for Hdac1 in liver and pancreas formation.
Article in Developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 79 citations in OpenAlex.
- Transcriptomic regulation of pancreatic acinar cell homeostasis and plasticity.Biochemical Society transactions · 2026Review
- Using different zebrafish models to explore liver regeneration.Frontiers in cell and developmental biology · 2024Review
- The role of noncoding RNAs in pancreatic birth defects.Birth defects research · 2023Review
- Lineage tracing identifies heterogeneous hepatoblast contribution to cell lineages and postembryonic organ growth dynamics.PLoS biology · 2023Article
- A single-cell atlas of West African lungfish respiratory system reveals evolutionary adaptations to terrestrialization.Nature communications · 2023Article
- Review
- Pharmacological inhibition of HDAC1/3-interacting proteins induced morphological changes, and hindered the cell proliferation and migration of hepatocellular carcinoma cells.Environmental science and pollution research international · 2021Article
- A single-cell-resolution fate map of endoderm reveals demarcation of pancreatic progenitors by cell cycle.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Histones, Their Variants and Post-translational Modifications in Zebrafish Development.Frontiers in cell and developmental biology · 2020Review
- A whole organism small molecule screen identifies novel regulators of pancreatic endocrine development.Development (Cambridge, England) · 2019Article
- HDAC1-mediated repression of the retinoic acid-responsive gene ripply3 promotes second heart field development.PLoS genetics · 2019Article
- Hdac1 Regulates Differentiation of Bipotent Liver Progenitor Cells During Regeneration via Sox9b and Cdk8.Gastroenterology · 2019Article
- Histone H4 acetylation regulates behavioral inter-individual variability in zebrafish.Genome biology · 2018Article
- Making It New Again: Insight Into Liver Development, Regeneration, and Disease From Zebrafish Research.Current topics in developmental biology · 2017Review
- Zebrafish as an In Vivo Model to Assess Epigenetic Effects of Ionizing Radiation.International journal of molecular sciences · 2016Review
- Zebrafish Discoveries in Cancer Epigenetics.Advances in experimental medicine and biology · 2016Review
- Zebrafish as a disease model for studying human hepatocellular carcinoma.World journal of gastroenterology · 2015Review
- The lure of zebrafish in liver research: regulation of hepatic growth in development and regeneration.Current opinion in genetics & development · 2015Review
- Pattern of change in histone 3 lysine 9 acetylation and histone deacetylases in development of zebrafish embryo.Journal of genetics · 2014Article
- Valproic acid silencing of ascl1b/Ascl1 results in the failure of serotonergic differentiation in a zebrafish model of fetal valproate syndrome.Disease models & mechanisms · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Liver, pancreas and lung originate from the presumptive foregut in temporal and spatial proximity. This requires precisely orchestrated transcriptional activation and repression of organ-specific gene expression within the same cell. Here, we show distinct roles for the chromatin remodelling factor and transcriptional repressor Histone deacetylase 1 (Hdac1) in endodermal organogenesis in zebrafish. Loss of Hdac1 causes defects in timely liver specification and in subsequent differentiation. Mosaic analyses reveal a cell-autonomous requirement for hdac1 within the hepatic endoderm. Our studies further reveal specific functions for Hdac1 in pancreas development. Loss of hdac1 causes the formation of ectopic endocrine clusters anteriorly to the main islet, as well as defects in exocrine pancreas specification and differentiation. In addition, we observe defects in extrahepatopancreatic duct formation and morphogenesis. Finally, loss of hdac1 results in an expansion of the foregut endoderm in the domain from which the liver and pancreas originate. Our genetic studies demonstrate that Hdac1 is crucial for regulating distinct steps in endodermal organogenesis. This suggests a model in which Hdac1 may directly or indirectly restrict foregut fates while promoting hepatic and exocrine pancreatic specification and differentiation, as well as pancreatic endocrine islet morphogenesis. These findings establish zebrafish as a tractable system to investigate chromatin remodelling factor functions in controlling gene expression programmes in vertebrate endodermal organogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.