ArticleInternational journal of nanomedicine2008
Do blood-borne calcifying nanoparticles self-propagate?
Article in International journal of nanomedicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical implications of calcifying nanoparticles in dental diseases: a critical review.International journal of nanomedicine · 2014Pooled it
- A Comprehensive Review on Bio-Based Materials for Chronic Diabetic Wounds.Molecules (Basel, Switzerland) · 2023Review
- Apoptosis-mediated endothelial toxicity but not direct calcification or functional changes in anti-calcification proteins defines pathogenic effects of calcium phosphate bions.Scientific reports · 2016Article
- Cytotoxicity and apoptosis induced by nanobacteria in human breast cancer cells.International journal of nanomedicine · 2014Article
- Cytotoxicity induced by nanobacteria and nanohydroxyapatites in human choriocarcinoma cells.Nanoscale research letters · 2014Article
- The role of calcifying nanoparticles in biology and medicine.International journal of nanomedicine · 2012Review
- Characterization of biofilm formed by human-derived nanoparticles.Nanomedicine (London, England) · 2009Article
- Putative nanobacteria represent physiological remnants and culture by-products of normal calcium homeostasis.PloS one · 2009Article
- Calcifying nanoparticles associated encrusted urinary bladder cystitis.International journal of nanomedicine · 2008Article
- Nanobacteria in the pathogenesis of urolithiasis: Myth or reality?Indian journal of urology : IJU : journal of the Urological Society of IndiaReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nanotechnology industry is currently in the process of producing new nanoparticles. The biological activity of nanoparticles including adverse as well as beneficial effects tends to increase as their size decreases. The smaller the particles are, the greater their bioactivity and toxicity. Thus, one can easily conjecture the impact ofa nanoparticle if it could also self-replicate. This in vitro study reveals the self-propagating ability of unique calcifying nanoparticles (CNP) that can be as small as 50 nm in size and found in blood, blood products, and calcified soft tissues. Although specific detection techniques, morphological characteristics and biomineralizing properties of CNP are well established, their genomic information and self-propagating capability have always been challenged. The objective of this study is to document the propagation of CNP under physiological conditions, using inverted light microscopy (LM) and the Biostation IM time-lapse imaging system. Their detailed morphological structure was examined using scanning (SEM) and transmission (TEM) electron microscopy. This present study, in conjunction with previous findings of metabolic activity, antibiotic sensitivity, antibody specificity, morphological aspects and infectivity, validates CNP as self-replicators. Therefore these sterile-filterable, blood-borne nanoparticles should be of concern to the nanomedicine industry.
Indexed as
Identifiers
18686786PMC2527661What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.